Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.

dc.contributor.author

Akushevich, Igor V

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Veremeyeva, Galina A

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Dimov, Georgy P

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Ukraintseva, Svetlana V

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Arbeev, Konstantin G

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Akleyev, Alexander V

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Yashin, Anatoly I

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United States

dc.date.accessioned

2017-06-06T18:01:29Z

dc.date.available

2017-06-06T18:01:29Z

dc.date.issued

2010-09

dc.description.abstract

A new model of the hematopoietic system for humans chronically exposed to ionizing radiation allows for quantitative description of the initial hematopoiesis inhibition and subsequent increase in the risks of late stochastic effects such as leukemia. This model describes the dynamics of the hematopoietic stem cell compartment as well as the dynamics of each of the three blood cell types (leukocytes, erythrocytes, and platelets). The model parameters are estimated from the results of other experiments. They include the steady-state numbers of hematopoietic stem cells and peripheral blood cell lines for an unexposed organism, amplification parameters for each blood cell line, parameters describing the proliferation and apoptosis, parameters of feedback functions regulating the steady-state numbers, and characteristics of radiosensitivity in respect to cell death and non-lethal cell damages. The dynamic model of hematopoiesis is applied to the data on a subcohort of the Techa River residents with hematological measurements (e.g., blood counts) performed in 1950-1956 (which totals to about 3,500 exposed individuals). Among well-described effects observed in these data are the slope values of the dose-effect curves describing the hematopoietic inhibition and the dose rate patterns of the fractions of cytopenic states (e.g., leukopenia, thrombocytopenia). The model has been further generalized by inclusion of the component describing the risk of late stochastic effects. The risks of the development of late effects (such as leukemia) in population groups with specific patterns of early reactions in hematopoiesis (such as leukopenia induced by ionizing radiation) are investigated using simulation studies and compared to data.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/20699693

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00004032-201009000-00007

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1538-5159

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https://hdl.handle.net/10161/14859

dc.language

eng

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Ovid Technologies (Wolters Kluwer Health)

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Health Phys

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10.1097/HP.0b013e3181c61dc1

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Apoptosis

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Blood Cell Count

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Blood Platelets

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Cell Differentiation

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Cell Proliferation

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Cohort Studies

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Environmental Exposure

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Erythrocytes

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Hematopoietic System

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Humans

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Leukocytes

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Models, Biological

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Mutagenesis

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Population Groups

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Radiation, Ionizing

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Stochastic Processes

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Time Factors

dc.title

Modeling deterministic effects in hematopoietic system caused by chronic exposure to ionizing radiation in large human cohorts.

dc.type

Journal article

duke.contributor.orcid

Arbeev, Konstantin G|0000-0002-4195-7832

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/20699693

pubs.begin-page

322

pubs.end-page

329

pubs.issue

3

pubs.organisational-group

Center for Population Health & Aging

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Duke

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Duke Cancer Institute

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Duke Population Research Center

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Duke Population Research Institute

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Institutes and Centers

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Institutes and Provost's Academic Units

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Physics

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Sanford School of Public Policy

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School of Medicine

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Social Science Research Institute

pubs.organisational-group

Staff

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Trinity College of Arts & Sciences

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

99

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