Mimicking effects of cholesterol in lipid bilayer membranes by self-assembled amphiphilic block copolymers.
| dc.contributor.author | Wang, Xiaoyuan | |
| dc.contributor.author | Xu, Shixin | |
| dc.contributor.author | Cohen, Fredric S | |
| dc.contributor.author | Zhang, Jiwei | |
| dc.contributor.author | Cai, Yongqiang | |
| dc.date.accessioned | 2023-08-05T14:56:00Z | |
| dc.date.available | 2023-08-05T14:56:00Z | |
| dc.date.issued | 2023-07 | |
| dc.date.updated | 2023-08-05T14:55:57Z | |
| dc.description.abstract | The effect of cholesterol on biological membranes is important in biochemistry. In this study, a polymer system is used to simulate the consequences of varying cholesterol content in membranes. The system consists of an AB-diblock copolymer, a hydrophilic homopolymer hA, and a hydrophobic rigid homopolymer C, corresponding to phospholipid, water, and cholesterol, respectively. The effect of the C-polymer content on the membrane is studied within the framework of a self-consistent field model. The results show that the liquid-crystal behavior of B and C has a great influence on the chemical potential of cholesterol in bilayer membranes. The effects of the interaction strength between components, characterized by the Flory-Huggins parameters and the Maier-Saupe parameter, were studied. Some consequences of adding a coil headgroup to the C-rod are presented. Results of our model are compared to experimental findings for cholesterol-containing lipid bilayer membranes. | |
| dc.identifier.issn | 1744-683X | |
| dc.identifier.issn | 1744-6848 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Royal Society of Chemistry (RSC) | |
| dc.relation.ispartof | Soft matter | |
| dc.relation.isversionof | 10.1039/d3sm00804e | |
| dc.subject | Cholesterol | |
| dc.subject | Polymers | |
| dc.subject | Lipid Bilayers | |
| dc.subject | Phospholipids | |
| dc.title | Mimicking effects of cholesterol in lipid bilayer membranes by self-assembled amphiphilic block copolymers. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Xu, Shixin|0000-0002-8207-7313 | |
| pubs.begin-page | 5487 | |
| pubs.end-page | 5501 | |
| pubs.issue | 29 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Kunshan University | |
| pubs.organisational-group | DKU Faculty | |
| pubs.publication-status | Published | |
| pubs.volume | 19 |
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