Mimicking effects of cholesterol in lipid bilayer membranes by self-assembled amphiphilic block copolymers.

dc.contributor.author

Wang, Xiaoyuan

dc.contributor.author

Xu, Shixin

dc.contributor.author

Cohen, Fredric S

dc.contributor.author

Zhang, Jiwei

dc.contributor.author

Cai, Yongqiang

dc.date.accessioned

2023-08-05T14:56:00Z

dc.date.available

2023-08-05T14:56:00Z

dc.date.issued

2023-07

dc.date.updated

2023-08-05T14:55:57Z

dc.description.abstract

The effect of cholesterol on biological membranes is important in biochemistry. In this study, a polymer system is used to simulate the consequences of varying cholesterol content in membranes. The system consists of an AB-diblock copolymer, a hydrophilic homopolymer hA, and a hydrophobic rigid homopolymer C, corresponding to phospholipid, water, and cholesterol, respectively. The effect of the C-polymer content on the membrane is studied within the framework of a self-consistent field model. The results show that the liquid-crystal behavior of B and C has a great influence on the chemical potential of cholesterol in bilayer membranes. The effects of the interaction strength between components, characterized by the Flory-Huggins parameters and the Maier-Saupe parameter, were studied. Some consequences of adding a coil headgroup to the C-rod are presented. Results of our model are compared to experimental findings for cholesterol-containing lipid bilayer membranes.

dc.identifier.issn

1744-683X

dc.identifier.issn

1744-6848

dc.identifier.uri

https://hdl.handle.net/10161/28678

dc.language

eng

dc.publisher

Royal Society of Chemistry (RSC)

dc.relation.ispartof

Soft matter

dc.relation.isversionof

10.1039/d3sm00804e

dc.subject

Cholesterol

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Polymers

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Lipid Bilayers

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Phospholipids

dc.title

Mimicking effects of cholesterol in lipid bilayer membranes by self-assembled amphiphilic block copolymers.

dc.type

Journal article

duke.contributor.orcid

Xu, Shixin|0000-0002-8207-7313

pubs.begin-page

5487

pubs.end-page

5501

pubs.issue

29

pubs.organisational-group

Duke

pubs.organisational-group

Duke Kunshan University

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DKU Faculty

pubs.publication-status

Published

pubs.volume

19

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