Biomarkers of Gastrointestinal Disease in Cheetahs (Acinonyx Jubatus)

dc.contributor.author

Fox, Lana

dc.contributor.author

Haefele, Holly

dc.contributor.author

Uelmen, Johnny

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Hoppes, Sharman

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Swenson, Julie

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Tolbert, M Katherine

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Suchodolski, Jan S

dc.contributor.author

Steiner, Jörg M

dc.date.accessioned

2023-04-14T20:28:03Z

dc.date.available

2023-04-14T20:28:03Z

dc.date.issued

2021-09-01

dc.date.updated

2023-04-14T20:28:03Z

dc.description.abstract

Gastrointestinal disease is a common clinical problem in captive cheetahs (Acinonyx jubatus). It is reported that gastritis affects the vast majority of the captive population of cheetahs. Pancreatitis and acute and chronic enteritis have also been reported. These issues pose significant long-term health and welfare implications for cheetahs. Cobalamin, folate, methylmalonic acid (MMA), gastrin, feline pancreatic-specific lipase immunoreactivity (fPLI), and feline trypsin-like immunoreactivity (fTLI) immunoassays are important biomarkers of gastrointestinal disease in domestic cats. The goal of this study was to determine if these immunoassays validated in domestic cats could be used clinically in cheetahs, by establishing reference intervals (RI) for these biomarkers in cheetahs. A cohort of 40 clinically healthy cheetahs was selected from three zoological institutions on the basis of being free of clinical gastrointestinal disease and extra-gastrointestinal disease that could affect biomarkers, as well as having banked frozen serum. Cheetah biomarker RI, with domestic cat RI for comparison in parentheses, are as follows: Cobalamin 470-618 pg/ml (290-1500 pg/ml), folate 2.2-15.7 ng/ml (9.7-21.6 ng/ml), MMA 365-450 nM/L (139-897 nM/L), fPLI 0.5-1.2 μg/L (0-4 μg/L), and gastrin 30-50 pg/ml (<10-39.5 pg/ml). This study shows that RI for gastrointestinal biomarkers can be notably different, even between species that are as closely related as the domestic cat and the cheetah. Additionally, it was found that the fTLI assay does not cross-immunoreact with cheetahs. In conclusion, this study emphasizes the importance of developing species-specific RI for biomarker assays and using caution when extrapolating RI from other species.

dc.identifier.issn

1042-7260

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https://hdl.handle.net/10161/27050

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American Association of Zoo Veterinarians

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Journal of Zoo and Wildlife Medicine

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10.1638/2021-0012

dc.title

Biomarkers of Gastrointestinal Disease in Cheetahs (Acinonyx Jubatus)

dc.type

Journal article

duke.contributor.orcid

Uelmen, Johnny|0000-0003-3057-5107

pubs.begin-page

886

pubs.end-page

892

pubs.issue

3

pubs.organisational-group

Duke

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Trinity College of Arts & Sciences

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Staff

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Evolutionary Anthropology

pubs.publication-status

Published

pubs.volume

52

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