A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Liu, Yang

Ashton, Jeffrey R

Moding, Everett J

Yuan, Hsiangkuo

Register, Janna K

Fales, Andrew M

Choi, Jaeyeon

Whitley, Melodi J

Zhao, Xiaoguang

Qi, Yi

Ma, Yan

Vaidyanathan, Ganesan

Zalutsky, Michael R

Kirsch, David G

Badea, Cristian T

Vo-Dinh, Tuan

Australia

2015-12-03T18:28:54Z

2015

Nanomedicine has attracted increasing attention in recent years, because it offers great promise to provide personalized diagnostics and therapy with improved treatment efficacy and specificity. In this study, we developed a gold nanostar (GNS) probe for multi-modality theranostics including surface-enhanced Raman scattering (SERS) detection, x-ray computed tomography (CT), two-photon luminescence (TPL) imaging, and photothermal therapy (PTT). We performed radiolabeling, as well as CT and optical imaging, to investigate the GNS probe's biodistribution and intratumoral uptake at both macroscopic and microscopic scales. We also characterized the performance of the GNS nanoprobe for in vitro photothermal heating and in vivo photothermal ablation of primary sarcomas in mice. The results showed that 30-nm GNS have higher tumor uptake, as well as deeper penetration into tumor interstitial space compared to 60-nm GNS. In addition, we found that a higher injection dose of GNS can increase the percentage of tumor uptake. We also demonstrated the GNS probe's superior photothermal conversion efficiency with a highly concentrated heating effect due to a tip-enhanced plasmonic effect. In vivo photothermal therapy with a near-infrared (NIR) laser under the maximum permissible exposure (MPE) led to ablation of aggressive tumors containing GNS, but had no effect in the absence of GNS. This multifunctional GNS probe has the potential to be used for in vivo biosensing, preoperative CT imaging, intraoperative detection with optical methods (SERS and TPL), as well as image-guided photothermal therapy.

https://www.ncbi.nlm.nih.gov/pubmed/26155311

thnov05p0946

1838-7640

https://hdl.handle.net/10161/11045

eng

Ivyspring International Publisher

Theranostics

10.7150/thno.11974

CT

Gold nanostars

SERS

biodistribution

nanoparticles

photothermal therapy

theranostics

tumor imaging

Animals

Gold

Humans

Hyperthermia, Induced

Mice

Models, Animal

Optical Imaging

Sarcoma

Theranostic Nanomedicine

Treatment Outcome

A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy.

Journal article

Whitley, Melodi J|0000-0002-8163-6881

Vaidyanathan, Ganesan|0000-0003-3041-8275

Zalutsky, Michael R|0000-0002-5456-0324

Badea, Cristian T|0000-0002-1850-2522

https://www.ncbi.nlm.nih.gov/pubmed/26155311

946

960

9

Basic Science Departments

Biomedical Engineering

Chemistry

Clinical Science Departments

Duke

Duke Cancer Institute

Institutes and Centers

Pathology

Pharmacology & Cancer Biology

Pratt School of Engineering

Radiation Oncology

Radiology

School of Medicine

Trinity College of Arts & Sciences

Published online

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