Adoption of direct-acting antiviral medications for hepatitis C: a retrospective observational study.
| dc.contributor.author | Zullig, Leah L | |
| dc.contributor.author | Bhatia, Haresh L | |
| dc.contributor.author | Gellad, Ziad F | |
| dc.contributor.author | Eatherly, Mark | |
| dc.contributor.author | Henderson, Rochelle | |
| dc.contributor.author | Bosworth, Hayden B | |
| dc.date.accessioned | 2022-08-01T13:19:50Z | |
| dc.date.available | 2022-08-01T13:19:50Z | |
| dc.date.issued | 2019-07-25 | |
| dc.date.updated | 2022-08-01T13:19:46Z | |
| dc.description.abstract | BackgroundApproximately 3.5 million Americans are infected with the hepatitis C virus (HCV). Although many patients with HCV are asymptomatic, HCV is the leading cause of infection-related death in the U.S. With advances in curative medication therapy for HCV, many of these deaths are preventable. Access to innovative therapies may be unevenly distributed. Our objective was to describe medication prescribers' adoption of innovative HCV pharmacotherapy across prescriber, geographical location, and time.MethodsThis is a retrospective, secondary data analysis among a national cohort of patients prescribed direct-acting antiviral HCV medications with curative intent. We assessed prescriptions by time, geographic location, and provider type.ResultsThe peak of the adoption rate occurred within 45 days; nearly one-sixth of all prescribers had already prescribed one of the new drugs. Geographical regions (Midwest, South, and West all p ≥ 0.05) nor gender (p = 0.455) of a prescriber impacted adoption. Similarly, patient income did not influence the likelihood of a prescriber to adopt the new drugs earlier (p = 0.175). Gastroenterologists or hepatologists were more likely earlier adopters compared to primary care physicians (p = 0.01).ConclusionsBecause of the relative advantage of newer therapies, we anticipated that there would be an initial surge as early adopters prescribed the new medications and use would dwindle over time as the initial HCV cohort was cured. The data demonstrate that our hypothesis is essentially supported. There is a reduction in prescriptions at approximately 5 months post-approval and treatment is typically required for 3 months. There has been a surge in clinicians' adoption of innovative HCV treatments. As patients are cured of their infection, we anticipate a decreased need for chronic management of HCV.Trial registrationNot applicable. | |
| dc.identifier | 10.1186/s12913-019-4349-x | |
| dc.identifier.issn | 1472-6963 | |
| dc.identifier.issn | 1472-6963 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | BMC health services research | |
| dc.relation.isversionof | 10.1186/s12913-019-4349-x | |
| dc.subject | Humans | |
| dc.subject | Hepatitis C | |
| dc.subject | Antiviral Agents | |
| dc.subject | Therapies, Investigational | |
| dc.subject | Retrospective Studies | |
| dc.subject | Geography | |
| dc.subject | Time Factors | |
| dc.subject | Adult | |
| dc.subject | Physicians | |
| dc.subject | United States | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Healthcare Disparities | |
| dc.subject | Drug Prescriptions | |
| dc.subject | Practice Patterns, Physicians' | |
| dc.title | Adoption of direct-acting antiviral medications for hepatitis C: a retrospective observational study. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Zullig, Leah L|0000-0002-6638-409X | |
| duke.contributor.orcid | Bosworth, Hayden B|0000-0001-6188-9825 | |
| pubs.begin-page | 521 | |
| pubs.issue | 1 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Fuqua School of Business | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Staff | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Family Medicine and Community Health | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, Gastroenterology | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.organisational-group | Duke - Margolis Center for Health Policy | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
| pubs.organisational-group | Innovation & Entrepreneurship Initiative | |
| pubs.publication-status | Published | |
| pubs.volume | 19 |
Files
Original bundle
- Name:
- Adoption of direct-acting antiviral medications for hepatitis C a retrospective observational study.pdf
- Size:
- 683.36 KB
- Format:
- Adobe Portable Document Format