Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.

dc.contributor.author

Gonzalez-Gronow, Mario

dc.contributor.author

Gopal, Udhayakumar

dc.contributor.author

Austin, Richard C

dc.contributor.author

Pizzo, Salvatore V

dc.date.accessioned

2021-06-01T20:00:42Z

dc.date.available

2021-06-01T20:00:42Z

dc.date.issued

2021-05-07

dc.date.updated

2021-06-01T20:00:39Z

dc.description.abstract

The 78 kDa glucose-regulated protein (GRP78) is an endoplasmic reticulum (ER)-resident molecular chaperone. GRP78 is a member of the 70 kDa heat shock family of proteins involved in correcting and clearing misfolded proteins in the ER. In response to cellular stress, GRP78 escapes from the ER and moves to the plasma membrane where it (a) functions as a receptor for many ligands, and (b) behaves as an autoantigen for autoantibodies that contribute to human disease and cancer. Cell surface GRP78 (csGRP78) associates with the major histocompatibility complex class I (MHC-I), and is the port of entry for several viruses, including the predictive binding of the novel SARS-CoV-2. Furthermore, csGRP78 is found in association with partners as diverse as the teratocarcinoma-derived growth factor 1 (Cripto), the melanocortin-4 receptor (MC4R) and the DnaJ-like protein MTJ-1. CsGRP78 also serves as a receptor for a large variety of ligands including activated α2 -macroglobulin (α2 M*), plasminogen kringle 5 (K5), microplasminogen, the voltage-dependent anion channel (VDAC), tissue factor (TF), and the prostate apoptosis response-4 protein (Par-4). In this review, we discuss the mechanisms involved in the translocation of GRP78 from the ER to the cell surface, and the role of secreted GRP78 and its autoantibodies in cancer and neurological disorders.

dc.identifier.issn

1521-6543

dc.identifier.issn

1521-6551

dc.identifier.uri

https://hdl.handle.net/10161/23312

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

IUBMB life

dc.relation.isversionof

10.1002/iub.2502

dc.subject

GRP78

dc.subject

GRP78 autoantibodies

dc.subject

GRP78 signaling

dc.subject

cancer

dc.subject

heat shock protein

dc.subject

neurological disorders

dc.title

Glucose-regulated protein (GRP78) is an important cell surface receptor for viral invasion, cancers, and neurological disorders.

dc.type

Journal article

duke.contributor.orcid

Gonzalez-Gronow, Mario|0000-0002-3548-7176

pubs.begin-page

843

pubs.end-page

854

pubs.issue

6

pubs.organisational-group

School of Medicine

pubs.organisational-group

Pathology

pubs.organisational-group

Duke

pubs.organisational-group

Clinical Science Departments

pubs.publication-status

Published

pubs.volume

73

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
Glucose-regulated protein (GRP78) is an important cell.pdf
Size:
2.16 MB
Format:
Adobe Portable Document Format
Description:
Published version