A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.

dc.contributor.author

Fu, Henry L

dc.contributor.author

Yu, Bing

dc.contributor.author

Lo, Justin Y

dc.contributor.author

Palmer, Greg M

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Kuech, Thomas F

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Ramanujam, Nimmi

dc.coverage.spatial

United States

dc.date.accessioned

2011-06-21T17:27:43Z

dc.date.issued

2010-06-07

dc.description.abstract

The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)').

dc.description.version

Version of Record

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/20588390

dc.identifier

199840

dc.identifier.eissn

1094-4087

dc.identifier.uri

https://hdl.handle.net/10161/4239

dc.language

eng

dc.language.iso

en_US

dc.publisher

Optica Publishing Group

dc.relation.ispartof

Opt Express

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Optics Express

dc.subject

Computer Simulation

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Imaging, Three-Dimensional

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Optical Phenomena

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Phantoms, Imaging

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Spectrum Analysis

dc.title

A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.

dc.title.alternative
dc.type

Journal article

duke.contributor.orcid

Palmer, Greg M|0000-0003-2955-8297

duke.date.pubdate

2010-6-7

duke.description.issue

12

duke.description.volume

18

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/20588390

pubs.begin-page

12630

pubs.end-page

12645

pubs.issue

12

pubs.organisational-group

Basic Science Departments

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Biomedical Engineering

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Clinical Science Departments

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Duke

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Duke Cancer Institute

pubs.organisational-group

Duke Science & Society

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Global Health Institute

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Initiatives

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Institutes and Centers

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Institutes and Provost's Academic Units

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Pharmacology & Cancer Biology

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Pratt School of Engineering

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Radiation Oncology

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School of Medicine

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University Institutes and Centers

pubs.publication-status

Published

pubs.volume

18

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