A low-cost, portable, and quantitative spectral imaging system for application to biological tissues.
dc.contributor.author | Fu, Henry L | |
dc.contributor.author | Yu, Bing | |
dc.contributor.author | Lo, Justin Y | |
dc.contributor.author | Palmer, Greg M | |
dc.contributor.author | Kuech, Thomas F | |
dc.contributor.author | Ramanujam, Nimmi | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2011-06-21T17:27:43Z | |
dc.date.issued | 2010-06-07 | |
dc.description.abstract | The ability of diffuse reflectance spectroscopy to extract quantitative biological composition of tissues has been used to discern tissue types in both pre-clinical and clinical cancer studies. Typically, diffuse reflectance spectroscopy systems are designed for single-point measurements. Clinically, an imaging system would provide valuable spatial information on tissue composition. While it is feasible to build a multiplexed fiber-optic probe based spectral imaging system, these systems suffer from drawbacks with respect to cost and size. To address these we developed a compact and low cost system using a broadband light source with an 8-slot filter wheel for illumination and silicon photodiodes for detection. The spectral imaging system was tested on a set of tissue mimicking liquid phantoms which yielded an optical property extraction accuracy of 6.40 +/- 7.78% for the absorption coefficient (micro(a)) and 11.37 +/- 19.62% for the wavelength-averaged reduced scattering coefficient (micro(s)'). | |
dc.description.version | Version of Record | |
dc.identifier | ||
dc.identifier | 199840 | |
dc.identifier.eissn | 1094-4087 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.language.iso | en_US | |
dc.publisher | Optica Publishing Group | |
dc.relation.ispartof | Opt Express | |
dc.relation.journal | Optics Express | |
dc.subject | Computer Simulation | |
dc.subject | Imaging, Three-Dimensional | |
dc.subject | Optical Phenomena | |
dc.subject | Phantoms, Imaging | |
dc.subject | Spectrum Analysis | |
dc.title | A low-cost, portable, and quantitative spectral imaging system for application to biological tissues. | |
dc.title.alternative | ||
dc.type | Journal article | |
duke.contributor.orcid | Palmer, Greg M|0000-0003-2955-8297 | |
duke.date.pubdate | 2010-6-7 | |
duke.description.issue | 12 | |
duke.description.volume | 18 | |
pubs.author-url | ||
pubs.begin-page | 12630 | |
pubs.end-page | 12645 | |
pubs.issue | 12 | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Biomedical Engineering | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Science & Society | |
pubs.organisational-group | Global Health Institute | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Pharmacology & Cancer Biology | |
pubs.organisational-group | Pratt School of Engineering | |
pubs.organisational-group | Radiation Oncology | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 18 |