A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses.
| dc.contributor.author | McClain, Micah T | |
| dc.contributor.author | Nicholson, Bradly P | |
| dc.contributor.author | Park, Lawrence P | |
| dc.contributor.author | Liu, Tzu-Yu | |
| dc.contributor.author | Hero, Alfred O | |
| dc.contributor.author | Tsalik, Ephraim L | |
| dc.contributor.author | Zaas, Aimee K | |
| dc.contributor.author | Veldman, Timothy | |
| dc.contributor.author | Hudson, Lori L | |
| dc.contributor.author | Lambkin-Williams, Robert | |
| dc.contributor.author | Gilbert, Anthony | |
| dc.contributor.author | Burke, Thomas | |
| dc.contributor.author | Nichols, Marshall | |
| dc.contributor.author | Ginsburg, Geoffrey S | |
| dc.contributor.author | Woods, Christopher W | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2016-04-02T01:02:55Z | |
| dc.date.issued | 2016-01 | |
| dc.description.abstract | Early, presymptomatic intervention with oseltamivir (corresponding to the onset of a published host-based genomic signature of influenza infection) resulted in decreased overall influenza symptoms (aggregate symptom scores of 23.5 vs 46.3), more rapid resolution of clinical disease (20 hours earlier), reduced viral shedding (total median tissue culture infectious dose [TCID50] 7.4 vs 9.7), and significantly reduced expression of several inflammatory cytokines (interferon-γ, tumor necrosis factor-α, interleukin-6, and others). The host genomic response to influenza infection is robust and may provide the means for early detection, more timely therapeutic interventions, a meaningful reduction in clinical disease, and an effective molecular means to track response to therapy. | |
| dc.identifier | ||
| dc.identifier | ofw007 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | Open Forum Infect Dis | |
| dc.relation.isversionof | 10.1093/ofid/ofw007 | |
| dc.subject | gene expression | |
| dc.subject | genomic | |
| dc.subject | influenza | |
| dc.subject | oseltamivir | |
| dc.title | A Genomic Signature of Influenza Infection Shows Potential for Presymptomatic Detection, Guiding Early Therapy, and Monitoring Clinical Responses. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Tsalik, Ephraim L|0000-0002-6417-2042 | |
| duke.contributor.orcid | Burke, Thomas|0000-0003-0592-5822 | |
| duke.contributor.orcid | Ginsburg, Geoffrey S|0000-0003-4739-9808 | |
| duke.contributor.orcid | Woods, Christopher W|0000-0001-7240-2453 | |
| pubs.author-url | ||
| pubs.begin-page | ofw007 | |
| pubs.issue | 1 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biomedical Engineering | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Global Health Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Cardiology | |
| pubs.organisational-group | Medicine, Infectious Diseases | |
| pubs.organisational-group | Molecular Genetics and Microbiology | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | School of Nursing | |
| pubs.organisational-group | School of Nursing - Secondary Group | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published online | |
| pubs.volume | 3 |
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