Improving blood pressure control through a clinical pharmacist outreach program in patients with diabetes mellitus in 2 high-performing health systems: the adherence and intensification of medications cluster randomized, controlled pragmatic trial.
| dc.contributor.author | Heisler, Michele | |
| dc.contributor.author | Hofer, Timothy P | |
| dc.contributor.author | Schmittdiel, Julie A | |
| dc.contributor.author | Selby, Joe V | |
| dc.contributor.author | Klamerus, Mandi L | |
| dc.contributor.author | Bosworth, Hayden B | |
| dc.contributor.author | Bermann, Martin | |
| dc.contributor.author | Kerr, Eve A | |
| dc.date.accessioned | 2024-02-01T16:45:57Z | |
| dc.date.available | 2024-02-01T16:45:57Z | |
| dc.date.issued | 2012-06 | |
| dc.description.abstract | BackgroundEven in high-performing health systems, some patients with diabetes mellitus have poor blood pressure (BP) control because of poor medication adherence and lack of medication intensification. We examined whether the Adherence and Intensification of Medications intervention, a pharmacist-led intervention combining elements found in efficacy studies to lower BP, improved BP among patients with diabetes mellitus with persistent hypertension and poor refill adherence or insufficient medication intensification in 2 high-performing health systems.Methods and resultsWe conducted a prospective, multisite cluster randomized pragmatic trial with randomization of 16 primary care teams at 5 medical centers (3 Veterans Affairs and 2 Kaiser Permanente) to the Adherence and Intensification of Medications intervention or usual care. The primary outcome was relative change in systolic BP (SBP), comparing 1797 intervention with 2303 control team patients, from 6 months preceding to 6 months after the 14-month intervention period. We examined shorter-term changes in SBP as a secondary outcome. The mean SBP decrease from 6 months before to 6 months after the intervention period was ≈9 mm Hg in both arms. Mean SBPs of eligible intervention patients were 2.4 mm Hg lower (95% CI: -3.4 to -1.5; P<0.001) immediately after the intervention than those achieved by control patients.ConclusionsThe Adherence and Intensification of Medications program more rapidly lowered SBPs among intervention patients, but usual-care patients achieved equally low SBP levels by 6 months after the intervention period. These findings show the importance of evaluating in different real-life clinical settings programs found in efficacy trials to be effective before urging their widespread adoption in all settings.Clinical trial registrationURL: http://clinicaltrials.gov. Unique identifier: NCT00495794. | |
| dc.identifier | CIRCULATIONAHA.111.089169 | |
| dc.identifier.issn | 0009-7322 | |
| dc.identifier.issn | 1524-4539 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Ovid Technologies (Wolters Kluwer Health) | |
| dc.relation.ispartof | Circulation | |
| dc.relation.isversionof | 10.1161/circulationaha.111.089169 | |
| dc.rights.uri | ||
| dc.subject | Humans | |
| dc.subject | Hypertension | |
| dc.subject | Diabetes Complications | |
| dc.subject | Antihypertensive Agents | |
| dc.subject | Hypoglycemic Agents | |
| dc.subject | Treatment Outcome | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Prospective Studies | |
| dc.subject | Program Evaluation | |
| dc.subject | Risk Reduction Behavior | |
| dc.subject | Counseling | |
| dc.subject | Blood Pressure | |
| dc.subject | Aged | |
| dc.subject | Middle Aged | |
| dc.subject | Pharmacists | |
| dc.subject | Veterans | |
| dc.subject | Health Maintenance Organizations | |
| dc.subject | Primary Health Care | |
| dc.subject | Patient Care Team | |
| dc.subject | Female | |
| dc.subject | Male | |
| dc.subject | Medication Adherence | |
| dc.title | Improving blood pressure control through a clinical pharmacist outreach program in patients with diabetes mellitus in 2 high-performing health systems: the adherence and intensification of medications cluster randomized, controlled pragmatic trial. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Bosworth, Hayden B|0000-0001-6188-9825 | |
| pubs.begin-page | 2863 | |
| pubs.end-page | 2872 | |
| pubs.issue | 23 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences | |
| pubs.organisational-group | Medicine, General Internal Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Initiatives | |
| pubs.organisational-group | Duke Science & Society | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Duke Innovation & Entrepreneurship | |
| pubs.organisational-group | Psychiatry & Behavioral Sciences, Behavioral Medicine & Neurosciences | |
| pubs.organisational-group | Duke - Margolis Center For Health Policy | |
| pubs.publication-status | Published | |
| pubs.volume | 125 |
Files
Original bundle
- Name:
- Improving blood pressure control through a clinical pharmacist outreach program in patients with diabetes mellitus in 2 high.pdf
- Size:
- 904.2 KB
- Format:
- Adobe Portable Document Format