Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults.

Loading...
Thumbnail Image

Date

2011-10

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

90
views
37
downloads

Citation Stats

Abstract

Based on the multiple logistic regression analysis of data from a random sample of 1,023 old adults collected in Taiwan in 2000, we found that interactions between carrying the APOE4 allele and one of four life stress factors (relocated mainlander, living in a crowded household with six or more persons, living in an earthquake-damaged house, and monthly financial difficulty) significantly increased the odds ratio of poor self-reported health. Correlations between carrying the APOE4 allele and the life stress factors were ruled out by statistical tests. These life stress factors had a substantially larger adverse impact on self-reported health in APOE4 allele carriers than in noncarriers. This study provides evidence that interaction between carrying APOE4 allele and chronic life stressors has significant impacts on self-reported health while controlling for various sociodemographic and health behavior factors. Further studies with richer biomarkers are warranted for deeper understanding of the biological mechanisms.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1093/gerona/glr106

Publication Info

Zeng, Yi, Claude L Hughes, Megan A Lewis, Jianxin Li and Fengyu Zhang (2011). Interactions between life stress factors and carrying the APOE4 allele adversely impact self-reported health in old adults. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 66(10). 10.1093/gerona/glr106 Retrieved from https://hdl.handle.net/10161/17106.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Zeng

Yi Zeng

Professor in Medicine

(1) Socioeconomic, behavior, environmental and genetic determinants of healthy aging and healthy longevity;
(2) Factors related to elderly disability and mental health;
(3) Methods of family households and elderly living arrangements forecasting/analysis and their applications in health services and socioeconomic planning, and market studies;
(4) Policy analysis in population aging, social welfare, retirement, and fertility transitions.

Claude Lebernian Hughes

Consulting Professor of Obstetrics and Gynecology

Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.