Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.

dc.contributor.author

Lv, Yue-Bin

dc.contributor.author

Yin, Zhao-Xue

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Chei, Choy-Lye

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Qian, Han-Zhu

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Kraus, Virginia Byers

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Zhang, Juan

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Brasher, Melanie Sereny

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Shi, Xiao-Ming

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Matchar, David Bruce

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Zeng, Yi

dc.date.accessioned

2021-05-11T07:22:29Z

dc.date.available

2021-05-11T07:22:29Z

dc.date.issued

2015-03

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2021-05-11T07:22:28Z

dc.description.abstract

Objective

Low-density lipoprotein cholesterol (LDL-C) is a risk factor for survival in middle-aged individuals, but conflicting evidence exists on the relationship between LDL-C and all-cause mortality among the elderly. The goal of this study was to assess the relationship between LDL-C and all-cause mortality among Chinese oldest old (aged 80 and older) in a prospective cohort study.

Methods

LDL-C concentration was measured at baseline and all-cause mortality was calculated over a 3-year period. Multiple statistical models were used to adjust for demographic and biological covariates.

Results

During three years of follow-up, 447 of 935 participants died, and the overall all-cause mortality was 49.8%. Each 1 mmol/L increase of LDL-C concentration corresponded to a 19% decrease in 3-year all-cause mortality (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.71-0.92). The crude HR for abnormally higher LDL-C concentration (≥3.37 mmol/L) was 0.65 (0.41-1.03); and the adjusted HR was statistically significant around 0.60 (0.37-0.95) when adjusted for different sets of confounding factors. Results of sensitivity analysis also showed a significant association between higher LDL-C and lower mortality risk.

Conclusions

Among the Chinese oldest old, higher LDL-C level was associated with lower risk of all-cause mortality. Our findings suggested the necessity of re-evaluating the optimal level of LDL-C among the oldest old.
dc.identifier

S0021-9150(15)00031-3

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0021-9150

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1879-1484

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https://hdl.handle.net/10161/22876

dc.language

eng

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Elsevier BV

dc.relation.ispartof

Atherosclerosis

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10.1016/j.atherosclerosis.2015.01.002

dc.subject

Humans

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Treatment Outcome

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Mortality

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Risk Factors

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Sensitivity and Specificity

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Longitudinal Studies

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Follow-Up Studies

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Prospective Studies

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Longevity

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Aged

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Aged, 80 and over

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China

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Female

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Male

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Cholesterol, LDL

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Biomarkers

dc.title

Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.

dc.type

Journal article

duke.contributor.orcid

Kraus, Virginia Byers|0000-0001-8173-8258

duke.contributor.orcid

Matchar, David Bruce|0000-0003-3020-2108

pubs.begin-page

137

pubs.end-page

142

pubs.issue

1

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School of Medicine

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Duke Molecular Physiology Institute

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Orthopaedics

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Pathology

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Medicine, Rheumatology and Immunology

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Duke

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Institutes and Centers

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Clinical Science Departments

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Medicine

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Duke Clinical Research Institute

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Duke Global Health Institute

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Medicine, General Internal Medicine

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University Institutes and Centers

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Institutes and Provost's Academic Units

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Duke Population Research Institute

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Center for Population Health & Aging

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Duke Population Research Center

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Center for the Study of Aging and Human Development

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Medicine, Geriatrics

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Sanford School of Public Policy

pubs.publication-status

Published

pubs.volume

239

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