Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey.
dc.contributor.author | Lv, Yue-Bin | |
dc.contributor.author | Yin, Zhao-Xue | |
dc.contributor.author | Chei, Choy-Lye | |
dc.contributor.author | Qian, Han-Zhu | |
dc.contributor.author | Kraus, Virginia Byers | |
dc.contributor.author | Zhang, Juan | |
dc.contributor.author | Brasher, Melanie Sereny | |
dc.contributor.author | Shi, Xiao-Ming | |
dc.contributor.author | Matchar, David Bruce | |
dc.contributor.author | Zeng, Yi | |
dc.date.accessioned | 2021-05-11T07:22:29Z | |
dc.date.available | 2021-05-11T07:22:29Z | |
dc.date.issued | 2015-03 | |
dc.date.updated | 2021-05-11T07:22:28Z | |
dc.description.abstract | ObjectiveLow-density lipoprotein cholesterol (LDL-C) is a risk factor for survival in middle-aged individuals, but conflicting evidence exists on the relationship between LDL-C and all-cause mortality among the elderly. The goal of this study was to assess the relationship between LDL-C and all-cause mortality among Chinese oldest old (aged 80 and older) in a prospective cohort study.MethodsLDL-C concentration was measured at baseline and all-cause mortality was calculated over a 3-year period. Multiple statistical models were used to adjust for demographic and biological covariates.ResultsDuring three years of follow-up, 447 of 935 participants died, and the overall all-cause mortality was 49.8%. Each 1 mmol/L increase of LDL-C concentration corresponded to a 19% decrease in 3-year all-cause mortality (hazard ratio [HR] 0.81, 95% confidence interval [CI] 0.71-0.92). The crude HR for abnormally higher LDL-C concentration (≥3.37 mmol/L) was 0.65 (0.41-1.03); and the adjusted HR was statistically significant around 0.60 (0.37-0.95) when adjusted for different sets of confounding factors. Results of sensitivity analysis also showed a significant association between higher LDL-C and lower mortality risk.ConclusionsAmong the Chinese oldest old, higher LDL-C level was associated with lower risk of all-cause mortality. Our findings suggested the necessity of re-evaluating the optimal level of LDL-C among the oldest old. | |
dc.identifier | S0021-9150(15)00031-3 | |
dc.identifier.issn | 0021-9150 | |
dc.identifier.issn | 1879-1484 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Elsevier BV | |
dc.relation.ispartof | Atherosclerosis | |
dc.relation.isversionof | 10.1016/j.atherosclerosis.2015.01.002 | |
dc.subject | Humans | |
dc.subject | Treatment Outcome | |
dc.subject | Mortality | |
dc.subject | Risk Factors | |
dc.subject | Sensitivity and Specificity | |
dc.subject | Longitudinal Studies | |
dc.subject | Follow-Up Studies | |
dc.subject | Prospective Studies | |
dc.subject | Longevity | |
dc.subject | Aged | |
dc.subject | Aged, 80 and over | |
dc.subject | China | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Cholesterol, LDL | |
dc.subject | Biomarkers | |
dc.title | Low-density lipoprotein cholesterol was inversely associated with 3-year all-cause mortality among Chinese oldest old: data from the Chinese Longitudinal Healthy Longevity Survey. | |
dc.type | Journal article | |
duke.contributor.orcid | Kraus, Virginia Byers|0000-0001-8173-8258 | |
duke.contributor.orcid | Matchar, David Bruce|0000-0003-3020-2108 | |
pubs.begin-page | 137 | |
pubs.end-page | 142 | |
pubs.issue | 1 | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Duke Molecular Physiology Institute | |
pubs.organisational-group | Orthopaedics | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Medicine, Rheumatology and Immunology | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Duke Clinical Research Institute | |
pubs.organisational-group | Duke Global Health Institute | |
pubs.organisational-group | Medicine, General Internal Medicine | |
pubs.organisational-group | University Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Duke Population Research Institute | |
pubs.organisational-group | Center for Population Health & Aging | |
pubs.organisational-group | Duke Population Research Center | |
pubs.organisational-group | Center for the Study of Aging and Human Development | |
pubs.organisational-group | Medicine, Geriatrics | |
pubs.organisational-group | Sanford School of Public Policy | |
pubs.publication-status | Published | |
pubs.volume | 239 |
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