Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling.

dc.contributor.author

Rock, Jason R

dc.contributor.author

Randell, Scott H

dc.contributor.author

Hogan, Brigid LM

dc.coverage.spatial

England

dc.date.accessioned

2011-06-21T17:27:35Z

dc.date.issued

2010-09

dc.description.abstract

The small airways of the human lung undergo pathological changes in pulmonary disorders, such as chronic obstructive pulmonary disease (COPD), asthma, bronchiolitis obliterans and cystic fibrosis. These clinical problems impose huge personal and societal healthcare burdens. The changes, termed 'pathological airway remodeling', affect the epithelium, the underlying mesenchyme and the reciprocal trophic interactions that occur between these tissues. Most of the normal human airway is lined by a pseudostratified epithelium of ciliated cells, secretory cells and 6-30% basal cells, the proportion of which varies along the proximal-distal axis. Epithelial abnormalities range from hypoplasia (failure to differentiate) to basal- and goblet-cell hyperplasia, squamous- and goblet-cell metaplasia, dysplasia and malignant transformation. Mesenchymal alterations include thickening of the basal lamina, smooth muscle hyperplasia, fibrosis and inflammatory cell accumulation. Paradoxically, given the prevalence and importance of airway remodeling in lung disease, its etiology is poorly understood. This is due, in part, to a lack of basic knowledge of the mechanisms that regulate the differentiation, maintenance and repair of the airway epithelium. Specifically, little is known about the proliferation and differentiation of basal cells, a multipotent stem cell population of the pseudostratified airway epithelium. This Perspective summarizes what we know, and what we need to know, about airway basal cells to evaluate their contributions to normal and abnormal airway remodeling. We contend that exploiting well-described model systems using both human airway epithelial cells and the pseudostratified epithelium of the genetically tractable mouse trachea will enable crucial discoveries regarding the pathogenesis of airway disease.

dc.description.version

Version of Record

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/20699479

dc.identifier

dmm.006031

dc.identifier.eissn

1754-8411

dc.identifier.uri

https://hdl.handle.net/10161/4184

dc.language

eng

dc.language.iso

en_US

dc.publisher

The Company of Biologists

dc.relation.ispartof

Dis Model Mech

dc.relation.isversionof

10.1242/dmm.006031

dc.relation.journal

Disease Models & Mechanisms

dc.subject

Airway Remodeling

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Animals

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Epithelium

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Homeostasis

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Humans

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Respiratory System

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Respiratory Tract Diseases

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Stem Cells

dc.title

Airway basal stem cells: a perspective on their roles in epithelial homeostasis and remodeling.

dc.title.alternative
dc.type

Journal article

duke.date.pubdate

2010-10-sep

duke.description.issue

10-Sep

duke.description.volume

3

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/20699479

pubs.begin-page

545

pubs.end-page

556

pubs.issue

9-10

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Cell Biology

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Clinical Science Departments

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Duke

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Duke Cancer Institute

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Institutes and Centers

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Pediatrics

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School of Medicine

pubs.publication-status

Published

pubs.volume

3

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