Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission.
dc.contributor.author | Permar, Sallie R | |
dc.contributor.author | Fong, Youyi | |
dc.contributor.author | Vandergrift, Nathan | |
dc.contributor.author | Fouda, Genevieve G | |
dc.contributor.author | Gilbert, Peter | |
dc.contributor.author | Parks, Robert | |
dc.contributor.author | Jaeger, Frederick H | |
dc.contributor.author | Pollara, Justin | |
dc.contributor.author | Martelli, Amanda | |
dc.contributor.author | Liebl, Brooke E | |
dc.contributor.author | Lloyd, Krissey | |
dc.contributor.author | Yates, Nicole L | |
dc.contributor.author | Overman, R Glenn | |
dc.contributor.author | Shen, Xiaoying | |
dc.contributor.author | Whitaker, Kaylan | |
dc.contributor.author | Chen, Haiyan | |
dc.contributor.author | Pritchett, Jamie | |
dc.contributor.author | Solomon, Erika | |
dc.contributor.author | Friberg, Emma | |
dc.contributor.author | Marshall, Dawn J | |
dc.contributor.author | Whitesides, John F | |
dc.contributor.author | Gurley, Thaddeus C | |
dc.contributor.author | Von Holle, Tarra | |
dc.contributor.author | Martinez, David R | |
dc.contributor.author | Cai, Fangping | |
dc.contributor.author | Kumar, Amit | |
dc.contributor.author | Xia, Shi-Mao | |
dc.contributor.author | Lu, Xiaozhi | |
dc.contributor.author | Louzao, Raul | |
dc.contributor.author | Wilkes, Samantha | |
dc.contributor.author | Datta, Saheli | |
dc.contributor.author | Sarzotti-Kelsoe, Marcella | |
dc.contributor.author | Liao, Hua-Xin | |
dc.contributor.author | Ferrari, Guido | |
dc.contributor.author | Alam, S Munir | |
dc.contributor.author | Montefiori, David C | |
dc.contributor.author | Denny, Thomas N | |
dc.contributor.author | Moody, M Anthony | |
dc.contributor.author | Tomaras, Georgia D | |
dc.contributor.author | Gao, Feng | |
dc.contributor.author | Haynes, Barton F | |
dc.coverage.spatial | United States | |
dc.date.accessioned | 2016-06-01T14:02:18Z | |
dc.date.issued | 2015-07-01 | |
dc.description.abstract | Despite the wide availability of antiretroviral drugs, more than 250,000 infants are vertically infected with HIV-1 annually, emphasizing the need for additional interventions to eliminate pediatric HIV-1 infections. Here, we aimed to define humoral immune correlates of risk of mother-to-child transmission (MTCT) of HIV-1, including responses associated with protection in the RV144 vaccine trial. Eighty-three untreated, HIV-1-transmitting mothers and 165 propensity score-matched nontransmitting mothers were selected from the Women and Infants Transmission Study (WITS) of US nonbreastfeeding, HIV-1-infected mothers. In a multivariable logistic regression model, the magnitude of the maternal IgG responses specific for the third variable loop (V3) of the HIV-1 envelope was predictive of a reduced risk of MTCT. Neutralizing Ab responses against easy-to-neutralize (tier 1) HIV-1 strains also predicted a reduced risk of peripartum transmission in secondary analyses. Moreover, recombinant maternal V3-specific IgG mAbs mediated neutralization of autologous HIV-1 isolates. Thus, common V3-specific Ab responses in maternal plasma predicted a reduced risk of MTCT and mediated autologous virus neutralization, suggesting that boosting these maternal Ab responses may further reduce HIV-1 MTCT. | |
dc.identifier | ||
dc.identifier | 81593 | |
dc.identifier.eissn | 1558-8238 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | American Society for Clinical Investigation | |
dc.relation.ispartof | J Clin Invest | |
dc.relation.isversionof | 10.1172/JCI81593 | |
dc.subject | AIDS Vaccines | |
dc.subject | Antibodies, Neutralizing | |
dc.subject | Antibody Specificity | |
dc.subject | Antigens, Viral | |
dc.subject | Cohort Studies | |
dc.subject | Female | |
dc.subject | HIV Antibodies | |
dc.subject | HIV Envelope Protein gp120 | |
dc.subject | HIV Infections | |
dc.subject | HIV-1 | |
dc.subject | Humans | |
dc.subject | Immunoglobulin G | |
dc.subject | Infant | |
dc.subject | Infant, Newborn | |
dc.subject | Infectious Disease Transmission, Vertical | |
dc.subject | Logistic Models | |
dc.subject | Multivariate Analysis | |
dc.subject | Peptide Fragments | |
dc.subject | Pregnancy | |
dc.subject | Pregnancy Complications, Infectious | |
dc.subject | Risk Factors | |
dc.title | Maternal HIV-1 envelope-specific antibody responses and reduced risk of perinatal transmission. | |
dc.type | Journal article | |
duke.contributor.orcid | Ferrari, Guido|0000-0001-7747-3349 | |
duke.contributor.orcid | Alam, S Munir|0000-0003-0941-0703 | |
duke.contributor.orcid | Montefiori, David C|0000-0003-0856-6319 | |
duke.contributor.orcid | Moody, M Anthony|0000-0002-3890-5855 | |
duke.contributor.orcid | Tomaras, Georgia D|0000-0001-8076-1931 | |
duke.contributor.orcid | Gao, Feng|0000-0001-8903-0203 | |
pubs.author-url | ||
pubs.begin-page | 2702 | |
pubs.end-page | 2706 | |
pubs.issue | 7 | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Human Vaccine Institute | |
pubs.organisational-group | Global Health Institute | |
pubs.organisational-group | Immunology | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Duke Human Vaccine Institute | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.organisational-group | Molecular Genetics and Microbiology | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Pediatrics | |
pubs.organisational-group | Pediatrics, Infectious Diseases | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Staff | |
pubs.organisational-group | Surgery | |
pubs.organisational-group | Surgery, Surgical Sciences | |
pubs.organisational-group | Surgery, Surgical Sciences Section for AIDS Research & Development | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 125 |
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