International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia.

dc.contributor.author

Aliberti, Stefano

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Cook, Grayden S

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Babu, Bettina L

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Reyes, Luis F

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H Rodriguez, Alejandro

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Sanz, Francisco

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Soni, Nilam J

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Anzueto, Antonio

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Faverio, Paola

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Sadud, Ricardo Franco

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Muhammad, Irfan

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Prat, Cristina

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Vendrell, Ester

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Neves, Joao

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Kaimakamis, Evangelos

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Feneley, Andrew

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Swarnakar, Rajesh

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Franzetti, Fabio

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Carugati, Manuela

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Morosi, Manuela

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Monge, Elisa

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Restrepo, Marcos I

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GLIMP investigators

dc.date.accessioned

2024-01-25T17:21:27Z

dc.date.available

2024-01-25T17:21:27Z

dc.date.issued

2019-10

dc.description.abstract

Objective

Streptococcus pneumoniae is the most frequent bacterial pathogen isolated in subjects with Community-acquired pneumonia (CAP) worldwide. Limited data are available regarding the current global burden and risk factors associated with drug-resistant Streptococcus pneumoniae (DRSP) in CAP subjects. We assessed the multinational prevalence and risk factors for DRSP-CAP in a multinational point-prevalence study.

Design

The prevalence of DRSP-CAP was assessed by identification of DRSP in blood or respiratory samples among adults hospitalized with CAP in 54 countries. Prevalence and risk factors were compared among subjects that had microbiological testing and antibiotic susceptibility data. Multivariate logistic regressions were used to identify risk factors independently associated with DRSP-CAP.

Results

3,193 subjects were included in the study. The global prevalence of DRSP-CAP was 1.3% and continental prevalence rates were 7.0% in Africa, 1.2% in Asia, and 1.0% in South America, Europe, and North America, respectively. Macrolide resistance was most frequently identified in subjects with DRSP-CAP (0.6%) followed by penicillin resistance (0.5%). Subjects in Africa were more likely to have DRSP-CAP (OR: 7.6; 95%CI: 3.34-15.35, p<0.001) when compared to centres representing other continents.

Conclusions

This multinational point-prevalence study found a low global prevalence of DRSP-CAP that may impact guideline development and antimicrobial policies.
dc.identifier

S0163-4453(19)30199-9

dc.identifier.issn

0163-4453

dc.identifier.issn

1532-2742

dc.identifier.uri

https://hdl.handle.net/10161/29852

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

The Journal of infection

dc.relation.isversionof

10.1016/j.jinf.2019.07.004

dc.rights.uri

https://creativecommons.org/licenses/by-nc/4.0

dc.subject

GLIMP investigators

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Humans

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Streptococcus pneumoniae

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Pneumonia, Pneumococcal

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Community-Acquired Infections

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Anti-Bacterial Agents

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Hospitalization

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Prevalence

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Risk Factors

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Drug Resistance, Bacterial

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Cost of Illness

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Internationality

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Aged

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Aged, 80 and over

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Middle Aged

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Female

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Male

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Global Health

dc.title

International prevalence and risk factors evaluation for drug-resistant Streptococcus pneumoniae pneumonia.

dc.type

Journal article

duke.contributor.orcid

Carugati, Manuela|0000-0002-3187-5905

pubs.begin-page

300

pubs.end-page

311

pubs.issue

4

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

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Clinical Science Departments

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Institutes and Centers

pubs.organisational-group

Medicine

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Medicine, Infectious Diseases

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Medicine, Pulmonary, Allergy, and Critical Care Medicine

pubs.organisational-group

Duke Clinical Research Institute

pubs.publication-status

Published

pubs.volume

79

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