Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis

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10.1038/s41467-019-11618-7

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Han, Tao, Shulong Jiang, Hong Zheng, Qing Yin, Mengyu Xie, Margaret R Little, Xiu Yin, Ming Chen, et al. (2019). Interplay between c-Src and the APC/C co-activator Cdh1 regulates mammary tumorigenesis. Nature Communications, 10(1). 10.1038/s41467-019-11618-7 Retrieved from https://hdl.handle.net/10161/19230.

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Chen

Ming Chen

Associate Professor of Pathology

Our laboratory is interested in understanding the molecular and genetic events underlying cancer progression and metastasis. The focus of our work is a series of genetically engineered mouse models that faithfully recapitulate human disease. Using a combination of mouse genetics, omics technologies, cross-species analyses and in vitro approaches, we aim to identify cancer cell–intrinsic and –extrinsic mechanisms driving metastatic cancer progression, with a long–term goal of developing new therapeutic strategies for preventing and treating metastatic disease. 


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