Mechanical circulatory support for end-stage heart failure in repaired and palliated congenital heart disease.

dc.contributor.author

Clark, Joseph B

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Pauliks, Linda B

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Myers, John L

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Undar, Akif

dc.date.accessioned

2023-12-04T15:33:40Z

dc.date.available

2023-12-04T15:33:40Z

dc.date.issued

2011-05

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2023-12-04T15:33:39Z

dc.description.abstract

Approximately one in one hundred children is born with congenital heart disease. Most can be managed with corrective or palliative surgery but a small group will develop severe heart failure, leaving cardiac transplantation as the ultimate treatment option. Unfortunately, due to the inadequate number of available donor organs, only a small number of patients can benefit from this therapy, and mortality remains high for pediatric patients awaiting heart transplantation, especially compared to adults. The purpose of this review is to describe the potential role of mechanical circulatory support in this context and to review current experience. For patients with congenital heart disease, ventricular assist devices are most commonly used as a bridge to cardiac transplantation, an application which has been shown to have several important advantages over medical therapy alone or support with extracorporeal membrane oxygenation, including improved survival to transplant, less exposure to blood products with less immune sensitization, and improved organ function. While these devices may improve wait list mortality, the chronic shortage of donor organs for children is likely to remain a problem into the foreseeable future. Therefore, there is great interest in the development of mechanical ventricular assist devices as potential destination therapy for congenital heart disease patients with end-stage heart failure. This review first discusses the experience with the currently available ventricular assist devices in children with congenital heart disease, and then follows to discuss what devices are under development and may reach the bedside soon.

dc.identifier

CCR-7-102

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1573-403X

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1875-6557

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https://hdl.handle.net/10161/29464

dc.language

eng

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Bentham Science Publishers Ltd.

dc.relation.ispartof

Current cardiology reviews

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10.2174/157340311797484222

dc.subject

Humans

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Heart Defects, Congenital

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Heart Diseases

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Palliative Care

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Heart-Assist Devices

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Heart Transplantation

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Risk Factors

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Equipment Design

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Infant

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Tissue Donors

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Heart Failure

dc.title

Mechanical circulatory support for end-stage heart failure in repaired and palliated congenital heart disease.

dc.type

Journal article

pubs.begin-page

102

pubs.end-page

109

pubs.issue

2

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Surgery

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Surgery, Cardiovascular and Thoracic Surgery

pubs.publication-status

Published

pubs.volume

7

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