Does smoking have an impact on fusion rate in single-level anterior cervical discectomy and fusion with allograft and rigid plate fixation? Clinical article.

dc.contributor.author

Luszczyk, Myles

dc.contributor.author

Smith, Justin S

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Fischgrund, Jeffrey S

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Ludwig, Steven C

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Sasso, Rick C

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Shaffrey, Christopher I

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Vaccaro, Alexander R

dc.date.accessioned

2023-08-29T23:29:35Z

dc.date.available

2023-08-29T23:29:35Z

dc.date.issued

2013-11

dc.date.updated

2023-08-29T23:29:35Z

dc.description.abstract

Object

Although smoking has been shown to negatively affect fusion rates in patients undergoing multilevel fusions of the cervical and lumbar spine, the effect of smoking on fusion rates in patients undergoing single-level anterior cervical discectomy and fusion (ACDF) with allograft and plate fixation has yet to be thoroughly investigated. The objective of the present study was to address the effect of smoking on fusion rates in patients undergoing a 1-level ACDF with allograft and a locked anterior cervical plate.

Methods

This study is composed of patients from the control groups of 5 separate studies evaluating the use of an anterior cervical disc replacement to treat cervical radiculopathy. For each of the 5 studies the control group consisted of patients who underwent a 1-level ACDF with allograft and a locked cervical plate. The authors of the present study reviewed data obtained in a total of 573 patients; 156 patients were smokers and 417 were nonsmokers. A minimum follow-up period of 24 months was required for inclusion in this study. Fusion status was assessed by independent observers using lateral, neutral, and flexion/extension radiographs.

Results

An overall fusion rate of 91.4% was achieved in all 573 patients. A solid fusion was shown in 382 patients (91.6%) who were nonsmokers. Among patients who were smokers, 142 (91.0%) had radiographic evidence of a solid fusion. A 2-tailed Fisher exact test revealed a p value of 0.867, indicating no difference in the union rates between smokers and nonsmokers.

Conclusions

The authors found no statistically significant difference in fusion status between smokers and nonsmokers who underwent a single-level ACDF with allograft and a locked anterior cervical plate. Although the authors do not promote tobacco use, it appears that the use of allograft with a locked cervical plate in single-level ACDF among smokers produces similar fusion rates as it does in their nonsmoking counterparts.
dc.identifier.issn

1547-5654

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1547-5646

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https://hdl.handle.net/10161/28813

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eng

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Journal of Neurosurgery Publishing Group (JNSPG)

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Journal of neurosurgery. Spine

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10.3171/2013.7.spine13208

dc.subject

Cervical Vertebrae

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Humans

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Radiculopathy

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Radiography

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Treatment Outcome

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Spinal Fusion

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Diskectomy

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Retrospective Studies

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Follow-Up Studies

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Bone Plates

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Smoking

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Adult

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Intervertebral Disc

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Allografts

dc.title

Does smoking have an impact on fusion rate in single-level anterior cervical discectomy and fusion with allograft and rigid plate fixation? Clinical article.

dc.type

Journal article

duke.contributor.orcid

Shaffrey, Christopher I|0000-0001-9760-8386

pubs.begin-page

527

pubs.end-page

531

pubs.issue

5

pubs.organisational-group

Duke

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School of Medicine

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Clinical Science Departments

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Orthopaedic Surgery

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Neurosurgery

pubs.publication-status

Published

pubs.volume

19

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