StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease.
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ObjectiveSubthalamic deep brain stimulation (DBS) is an established therapy for Parkinson's disease. Connectomic DBS modeling is a burgeoning subfield of research aimed at characterizing the axonal connections activated by DBS. This article describes our approach and methods for evolving the StimVision software platform to meet the technical demands of connectomic DBS modeling in the subthalamic region.
Materials and methodsStimVision v2 was developed with Visualization Toolkit (VTK) libraries and integrates four major components: 1) medical image visualization, 2) axonal pathway visualization, 3) electrode positioning, and 4) stimulation calculation.
ResultsStimVision v2 implemented two key technological advances for connectomic DBS analyses in the subthalamic region. First was the application of anatomical axonal pathway models to patient-specific DBS models. Second was the application of a novel driving-force method to estimate the response of those axonal pathways to DBS. Example simulations with directional DBS electrodes and clinically defined therapeutic DBS settings are presented to demonstrate the general outputs of StimVision v2 models.
ConclusionsStimVision v2 provides the opportunity to evaluate patient-specific axonal pathway activation from subthalamic DBS using anatomically detailed pathway models and electrically detailed electric field distributions with interactive adjustment of the DBS electrode position and stimulation parameter settings.
Published Version (Please cite this version)
Noecker, Angela M, Anneke M Frankemolle-Gilbert, Bryan Howell, Mikkel V Petersen, Sinem Balta Beylergil, Aasef G Shaikh and Cameron C McIntyre (2021). StimVision v2: Examples and Applications in Subthalamic Deep Brain Stimulation for Parkinson's Disease. Neuromodulation : journal of the International Neuromodulation Society, 24(2). pp. 248–258. 10.1111/ner.13350 Retrieved from https://hdl.handle.net/10161/23859.
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My lab studies implantable and wearable devices for treating neurological impairment, namely with deep brain stimulation (DBS) and transcranial electrical stimulation (tES). Projects evolve through theoretical and preclinical stages of development, combining biophysical and dynamic causal modeling, medical imaging, and device prototyping, to test new concepts and strategies for these neurotechnologies. Noninvasive studies on tES are conducted in tissue phantoms and healthy human subjects in-house, and we collaborate with physicians to test new concepts in clinical populations.
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