Secondhand smoke is an important modifiable risk factor in sickle cell disease: A review of the current literature and areas for future research

Sadreameli, S Christy

Kopp, Benjamin T

Creary, Susan E

Eakin, Michelle N

McGrath-Morrow, Sharon

Strouse, John J

2017-01-02T03:06:38Z

2016-11-12

© 2016 by the authors; licensee MDPI, Basel, Switzerland.Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.

1660-4601

1661-7827

https://hdl.handle.net/10161/13333

MDPI AG

International Journal of Environmental Research and Public Health

10.3390/ijerph13111131

Secondhand smoke is an important modifiable risk factor in sickle cell disease: A review of the current literature and areas for future research

Journal article

Strouse, John J|0000-0003-0341-1457

11

Clinical Science Departments

Duke

Medicine

Medicine, Hematology

School of Medicine

Published

13