Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.

dc.contributor.author

Gamboa Arana, Olga Lucia

dc.contributor.author

Palmer, Hannah

dc.contributor.author

Dannhauer, Moritz

dc.contributor.author

Hile, Connor

dc.contributor.author

Liu, Sicong

dc.contributor.author

Hamdan, Rena

dc.contributor.author

Brito, Alexandra

dc.contributor.author

Cabeza, Roberto

dc.contributor.author

Davis, Simon W

dc.contributor.author

Peterchev, Angel V

dc.contributor.author

Sommer, Marc A

dc.contributor.author

Appelbaum, Lawrence G

dc.date.accessioned

2020-10-26T15:10:36Z

dc.date.available

2020-10-26T15:10:36Z

dc.date.issued

2020-10

dc.date.updated

2020-10-26T15:10:35Z

dc.description.abstract

Despite the widespread use of transcranial magnetic stimulation (TMS) in research and clinical care, the dose-response relations and neurophysiological correlates of modulatory effects remain relatively unexplored. To fill this gap, we studied modulation of visual processing as a function of TMS parameters. Our approach combined electroencephalography (EEG) with application of single pulse TMS to visual cortex as participants performed a motion perception task. During each participants' first visit, motion coherence thresholds, 64-channel visual evoked potentials (VEPs), and TMS resting motor thresholds (RMT) were measured. In second and third visits, single pulse TMS was delivered at one of two latencies, either 30 ms before the onset of motion or at the onset latency of the N2 VEP component derived from the first session. TMS was delivered at 0%, 80%, 100%, or 120% of RMT over the site of N2 peak activity, or at 120% over vertex. Behavioral results demonstrated a significant main effect of TMS timing on accuracy, with better performance when TMS was applied at the N2-Onset timing versus Pre-Onset, as well as a significant interaction, indicating that 80% intensity produced higher accuracy than other conditions at the N2-Onset. TMS effects on the P3 VEP showed reduced amplitudes in the 80% Pre-Onset condition, an increase for the 120% N2-Onset condition, and monotonic amplitude scaling with stimulation intensity. The N2 component was not affected by TMS. These findings reveal the influence of TMS intensity and timing on visual perception and electrophysiological responses, with optimal facilitation at stimulation intensities below RMT.

dc.identifier

S0028-3932(20)30254-2

dc.identifier.issn

0028-3932

dc.identifier.issn

1873-3514

dc.identifier.uri

https://hdl.handle.net/10161/21632

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

Neuropsychologia

dc.relation.isversionof

10.1016/j.neuropsychologia.2020.107581

dc.subject

Motion sensitive cortex

dc.subject

TMS

dc.subject

TMS Evoked potential

dc.subject

Transcranial magnetic stimulation

dc.subject

Visual evoked potential

dc.subject

Visual motion

dc.title

Intensity- and timing-dependent modulation of motion perception with transcranial magnetic stimulation of visual cortex.

dc.type

Journal article

duke.contributor.orcid

Cabeza, Roberto|0000-0001-7999-1182

duke.contributor.orcid

Davis, Simon W|0000-0002-5943-0756

duke.contributor.orcid

Peterchev, Angel V|0000-0002-4385-065X

duke.contributor.orcid

Sommer, Marc A|0000-0001-5061-763X

duke.contributor.orcid

Appelbaum, Lawrence G|0000-0002-3184-6725

pubs.begin-page

107581

pubs.organisational-group

School of Medicine

pubs.organisational-group

Psychology and Neuroscience

pubs.organisational-group

Duke Science & Society

pubs.organisational-group

Duke Institute for Brain Sciences

pubs.organisational-group

Psychiatry & Behavioral Sciences, Brain Stimulation and Neurophysiology

pubs.organisational-group

Duke

pubs.organisational-group

Trinity College of Arts & Sciences

pubs.organisational-group

Initiatives

pubs.organisational-group

Institutes and Provost's Academic Units

pubs.organisational-group

University Institutes and Centers

pubs.organisational-group

Psychiatry & Behavioral Sciences

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Center for Population Health & Aging

pubs.organisational-group

Duke-UNC Center for Brain Imaging and Analysis

pubs.organisational-group

Psychiatry & Behavioral Sciences, Geriatric Behavioral Health

pubs.organisational-group

Center for Cognitive Neuroscience

pubs.organisational-group

Duke Population Research Institute

pubs.organisational-group

Sanford School of Public Policy

pubs.organisational-group

Institutes and Centers

pubs.organisational-group

Biomedical Engineering

pubs.organisational-group

Electrical and Computer Engineering

pubs.organisational-group

Neurosurgery

pubs.organisational-group

Pratt School of Engineering

pubs.organisational-group

Neurobiology

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Pathology

pubs.organisational-group

Neurology, Behavioral Neurology

pubs.organisational-group

Neurology

pubs.publication-status

Published

pubs.volume

147

Files

Original bundle

Now showing 1 - 1 of 1
Loading...
Thumbnail Image
Name:
2020_GamboaArana_etal_Neuropsychologia.pdf
Size:
3.72 MB
Format:
Adobe Portable Document Format
Description:
Published version