Neural networks supporting autobiographical memory retrieval in posttraumatic stress disorder.

St Jacques, Peggy L

Kragel, Philip A

Rubin, David C

United States

2015-05-12T14:21:00Z

2013-09

Posttraumatic stress disorder (PTSD) affects the functional recruitment and connectivity between neural regions during autobiographical memory (AM) retrieval that overlap with default and control networks. Whether such univariate changes relate to potential differences in the contributions of the large-scale neural networks supporting cognition in PTSD is unknown. In the present functional MRI study, we employed independent-component analysis to examine the influence of the engagement of neural networks during the recall of personal memories in a PTSD group (15 participants) as compared to non-trauma-exposed healthy controls (14 participants). We found that the PTSD group recruited similar neural networks when compared to the controls during AM recall, including default-network subsystems and control networks, but group differences emerged in the spatial and temporal characteristics of these networks. First, we found spatial differences in the contributions of the anterior and posterior midline across the networks, and of the amygdala in particular, for the medial temporal subsystem of the default network. Second, we found temporal differences within the medial prefrontal subsystem of the default network, with less temporal coupling of this network during AM retrieval in PTSD relative to controls. These findings suggest that the spatial and temporal characteristics of the default and control networks potentially differ in a PTSD group versus healthy controls and contribute to altered recall of personal memory.

http://www.ncbi.nlm.nih.gov/pubmed/23483523

1531-135X

https://hdl.handle.net/10161/9762

eng

Springer Science and Business Media LLC

Cogn Affect Behav Neurosci

10.3758/s13415-013-0157-7

Adolescent

Adult

Brain Mapping

Case-Control Studies

Humans

Magnetic Resonance Imaging

Memory

Nerve Net

Stress Disorders, Post-Traumatic

Young Adult

Neural networks supporting autobiographical memory retrieval in posttraumatic stress disorder.

Journal article

http://www.ncbi.nlm.nih.gov/pubmed/23483523

554

566

3

Duke

Duke Institute for Brain Sciences

Institutes and Provost's Academic Units

Psychology and Neuroscience

Trinity College of Arts & Sciences

University Institutes and Centers

Published

13