Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed.
| dc.contributor.author | Petroccia, Heather M | |
| dc.contributor.author | Malajovich, Irina | |
| dc.contributor.author | Barsky, Andrew R | |
| dc.contributor.author | Ghiam, Alireza Fotouhi | |
| dc.contributor.author | Jones, Joshua | |
| dc.contributor.author | Wang, Chunhao | |
| dc.contributor.author | Zou, Wei | |
| dc.contributor.author | Teo, Boon-Keng Kevin | |
| dc.contributor.author | Dong, Lei | |
| dc.contributor.author | Metz, James M | |
| dc.contributor.author | Li, Taoran | |
| dc.date.accessioned | 2020-03-24T13:17:45Z | |
| dc.date.available | 2020-03-24T13:17:45Z | |
| dc.date.issued | 2019-01 | |
| dc.date.updated | 2020-03-24T13:17:43Z | |
| dc.description.abstract | Purpose: Spine SBRT requires treatment plans with steep dose gradients and tight limits to the cord maximal dose. A new dual-layer staggered 1-cm MLC in Halcyon™ treatment platform has improved leakage, speed, and DLG compared to 120-Millennium (0.5-cm) and High-Definition (0.25-cm) MLCs in the TrueBeam platform. Halcyon™ 2.0 with SX2 MLC modulates fluence with the upper and lower MLCs, while in Halcyon™ 1.0 with SX1 only the lower MLC modulates the fluence and the upper MLC functions as a back-up jaw. We investigated the effects of four MLC designs on plan quality for spine SBRT treatments. Methods: 15 patients previously treated at our institution were re-planned according to the NRG-BR-002 guidelines with a prescription of 3,000 cGy in 3 fractions, 6xFFF, 800 MU/min, and 3-arc VMAT technique. Planning objectives were adjusted manually by an experienced planner to generate optimal plans and kept the same for different MLCs within the same platform. Results: All treatment plans were able to achieve adequate target coverage while meeting NRG-BR002 dosimetric constraints. Planning parameters were evaluated including: conformity index, homogeneity index, gradient measure, and global point dose maximum. Delivery accuracy, modulation complexity, and delivery time were also analyzed for all MLCs. Conclusion: The Halcyon™ dual-layer MLC can generate comparable and clinically equivalent spine SBRT plans to TrueBeam plans with less rapid dose fall-off and lower conformity. MLC width leaf can impact maximum dose to organs at risk and plan quality, but does not cause limitations in achieving acceptable plans for spine SBRT treatments. | |
| dc.identifier.issn | 2234-943X | |
| dc.identifier.issn | 2234-943X | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Frontiers Media SA | |
| dc.relation.ispartof | Frontiers in Oncology | |
| dc.relation.isversionof | 10.3389/fonc.2019.00319 | |
| dc.subject | Halcyon™ | |
| dc.subject | SBRT | |
| dc.subject | modulation complexity score | |
| dc.subject | multi-leaf collimator | |
| dc.subject | plan quality | |
| dc.subject | spinal metastasis | |
| dc.title | Spine SBRT With Halcyon™: Plan Quality, Modulation Complexity, Delivery Accuracy, and Speed. | |
| dc.type | Journal article | |
| pubs.begin-page | 319 | |
| pubs.issue | APR | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Radiation Oncology | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.publication-status | Published | |
| pubs.volume | 9 |
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