Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient.
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2018-11-08
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Abstract
Transmitted drug resistance to the integrase strand transfer inhibitor (INSTI) class of antiretrovirals is very rare. We present a case of a treatment-naive female patient with human immunodeficiency virus harboring resistance to all INSTIs, including bictegravir and dolutegravir.
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McGee, Kara S, Nwora Lance Okeke, Christopher B Hurt and Mehri S McKellar (2018). Canary in the Coal Mine? Transmitted Mutations Conferring Resistance to All Integrase Strand Transfer Inhibitors in a Treatment-Naive Patient. Open forum infectious diseases, 5(11). p. ofy294. 10.1093/ofid/ofy294 Retrieved from https://hdl.handle.net/10161/20635.
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Scholars@Duke
Kara McGee
Nwora Lance Okeke
Mehri Sadri McKellar
Mehri McKellar, MD is a Professor in the Division of Infectious Diseases at Duke University Medical Center, and has almost 20 years of experience in treating persons with HIV (PWH). She serves as one of the primary providers in the Duke ID Clinic.
Since her arrival at Duke University in 2008, one of her major research interests has been on HIV prevention – including rapid HIV testing in non-traditional settings such as emergency rooms and in the community, and more recently, pre-exposure prophylaxis (PrEP). She serves as the Medical Director of the Duke PrEP clinic, which was the first dedicated PrEP Clinic in North Carolina and has seen >500 persons for HIV prevention. Her work with PrEP also extends to persons who inject drugs via syringe services programs and to individuals who are incarcerated.
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