Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.
| dc.contributor.author | Luu, David | |
| dc.contributor.author | Komisarow, Jordan | |
| dc.contributor.author | Mills, Brianna M | |
| dc.contributor.author | Vavilala, Monica S | |
| dc.contributor.author | Laskowitz, Daniel T | |
| dc.contributor.author | Mathew, Joseph | |
| dc.contributor.author | James, Michael L | |
| dc.contributor.author | Hernandez, Adrian | |
| dc.contributor.author | Sampson, John | |
| dc.contributor.author | Fuller, Matt | |
| dc.contributor.author | Ohnuma, Tetsu | |
| dc.contributor.author | Raghunathan, Karthik | |
| dc.contributor.author | Privratsky, Jamie | |
| dc.contributor.author | Bartz, Raquel | |
| dc.contributor.author | Krishnamoorthy, Vijay | |
| dc.date.accessioned | 2021-10-01T13:34:12Z | |
| dc.date.available | 2021-10-01T13:34:12Z | |
| dc.date.issued | 2021-01-13 | |
| dc.date.updated | 2021-10-01T13:34:11Z | |
| dc.description.abstract | Background/objectiveTraumatic brain injury (TBI) is a leading cause of morbidity, mortality, and disability in the USA. While cardiopulmonary dysfunction can result in poor outcomes following severe TBI, the impact of acute kidney injury (AKI) is poorly understood. We examined the association of severe AKI with hospital mortality and healthcare utilization following isolate severe TBI.MethodsWe conducted a retrospective cohort study using the National Trauma Data Bank from 2007 to 2014. We identified a cohort of adult patients with isolated severe TBI and described the incidence of severe AKI, corresponding to Acute Kidney Injury Network stage 3 disease or greater. We examined the association of severe AKI with the primary outcome of hospital mortality using multivariable logistic regression models. In secondary analyses, we examined the association of severe AKI with dialysis catheter placement, tracheostomy and gastrostomy utilization, and hospital length of stay.ResultsThere were 37,851 patients who experienced isolated severe TBI during the study period. Among these patients, 787 (2.1%) experienced severe (Stage 3 or greater) AKI. In multivariable models, the development of severe AKI in the hospital was associated with in-hospital mortality (OR 2.03, 95% CI 1.64-2.52), need for tracheostomy (OR 2.10, 95% CI 1.52-2.89), PEG tube placement (OR 1.88, 95% CI 1.45-2.45), and increased hospital length of stay (pā<ā0.001).ConclusionsThe overall incidence of severe AKI is relatively low (2.1%), but is associated with increased mortality and multiple markers of increased healthcare utilization following severe TBI. | |
| dc.identifier | 10.1007/s12028-020-01183-z | |
| dc.identifier.issn | 1541-6933 | |
| dc.identifier.issn | 1556-0961 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Springer Science and Business Media LLC | |
| dc.relation.ispartof | Neurocritical care | |
| dc.relation.isversionof | 10.1007/s12028-020-01183-z | |
| dc.subject | Acute kidney injury | |
| dc.subject | Healthcare utilization | |
| dc.subject | Traumatic brain injury | |
| dc.title | Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Komisarow, Jordan|0000-0003-3919-7931 | |
| duke.contributor.orcid | Laskowitz, Daniel T|0000-0003-3430-8815 | |
| duke.contributor.orcid | Mathew, Joseph|0000-0002-3815-4131 | |
| duke.contributor.orcid | James, Michael L|0000-0002-8715-5210 | |
| duke.contributor.orcid | Hernandez, Adrian|0000-0003-3387-9616 | |
| duke.contributor.orcid | Sampson, John|0000-0002-0104-7658 | |
| duke.contributor.orcid | Ohnuma, Tetsu|0000-0002-2303-6802 | |
| duke.contributor.orcid | Raghunathan, Karthik|0000-0003-2809-5374 | |
| duke.contributor.orcid | Privratsky, Jamie|0000-0003-3598-4911 | |
| duke.contributor.orcid | Krishnamoorthy, Vijay|0000-0002-1365-4121|0000-0003-4153-2348 | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Anesthesiology, Critical Care Medicine | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Anesthesiology | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Faculty | |
| pubs.organisational-group | Duke Clinical Research Institute | |
| pubs.organisational-group | Neurology, Neurocritical Care | |
| pubs.organisational-group | Anesthesiology, Neuroanesthesia | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Neurology | |
| pubs.organisational-group | Population Health Sciences | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Medicine, Cardiology | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Biomedical Engineering | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Immunology | |
| pubs.organisational-group | Orthopaedics | |
| pubs.organisational-group | Pathology | |
| pubs.organisational-group | Radiation Oncology | |
| pubs.organisational-group | Neurosurgery | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | Trauma, Acute, and Critical Care Surgery | |
| pubs.organisational-group | Surgery | |
| pubs.organisational-group | Anesthesiology, VA Anesthesiology Service | |
| pubs.publication-status | Published |
Files
Original bundle
- Name:
- Association of Severe Acute Kidney Injury with Mortality and Healthcare Utilization Following Isolated Traumatic Brain Injury.pdf
- Size:
- 703.83 KB
- Format:
- Adobe Portable Document Format