TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.

dc.contributor.author

Lindy, Amanda S

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Parekh, Puja K

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Zhu, Richard

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Kanju, Patrick

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Chintapalli, Sree V

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Tsvilovskyy, Volodymyr

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Patterson, Randen L

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Anishkin, Andriy

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van Rossum, Damian B

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Liedtke, Wolfgang B

dc.coverage.spatial

England

dc.date.accessioned

2016-03-01T14:18:23Z

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2014-09-02

dc.description.abstract

Animals need to sense and react to potentially dangerous environments. TRP ion channels participate in nociception, presumably via Ca(2+) influx, in most animal species. However, the relationship between ion permeation and animals' nocifensive behaviour is unknown. Here we use an invertebrate animal model with relevance for mammalian pain. We analyse the putative selectivity filter of OSM-9, a TRPV channel, in osmotic avoidance behaviour of Caenorhabditis elegans. Using mutagenized OSM-9 expressed in the head nociceptor neuron, ASH, we study nocifensive behaviour and Ca(2+) influx. Within the selectivity filter, M(601)-F(609), Y604G strongly reduces avoidance behaviour and eliminates Ca(2+) transients. Y604F also abolishes Ca(2+) transients in ASH, while sustaining avoidance behaviour, yet it disrupts behavioral plasticity. Homology modelling of the OSM-9 pore suggests that Y(604) may assume a scaffolding role. Thus, aromatic residues in the OSM-9 selectivity filter are critical for pain behaviour and ion permeation. These findings have relevance for understanding evolutionary roots of mammalian nociception.

dc.identifier

http://www.ncbi.nlm.nih.gov/pubmed/25178952

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ncomms5734

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2041-1723

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https://hdl.handle.net/10161/11664

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eng

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Springer Science and Business Media LLC

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Nat Commun

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10.1038/ncomms5734

dc.subject

Amino Acid Sequence

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Amino Acid Substitution

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Animals

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Avoidance Learning

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Caenorhabditis elegans

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Caenorhabditis elegans Proteins

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Calcium

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Calcium Signaling

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Gene Expression

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Ion Transport

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Models, Molecular

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Molecular Sequence Data

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Mutation

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Nerve Tissue Proteins

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Nociception

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Nociceptors

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Recombinant Fusion Proteins

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Sequence Alignment

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Structural Homology, Protein

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TRPV Cation Channels

dc.title

TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour.

dc.type

Journal article

duke.contributor.orcid

Liedtke, Wolfgang B|0000-0003-4166-5394

pubs.author-url

http://www.ncbi.nlm.nih.gov/pubmed/25178952

pubs.begin-page

4734

pubs.organisational-group

Anesthesiology

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Basic Science Departments

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Clinical Science Departments

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Duke

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Duke Institute for Brain Sciences

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Institutes and Provost's Academic Units

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Neurobiology

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Neurology

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Neurology, Headache and Pain

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School of Medicine

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University Institutes and Centers

pubs.publication-status

Published online

pubs.volume

5

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