Evaluation of Allostatic Load as a Mediator of Sleep and Kidney Outcomes in Black Americans.

Lunyera, Joseph

Davenport, Clemontina A

Jackson, Chandra L

Johnson, Dayna A

Bhavsar, Nrupen A

Sims, Mario

Scialla, Julia J

Stanifer, John W

Pendergast, Jane

McMullan, Ciaran J

Ricardo, Ana C

Boulware, L Ebony

Diamantidis, Clarissa J

2019-05-08T13:48:21Z

2019-05-08T13:48:21Z

2019-03

2019-05-08T13:48:20Z

Introduction:Poor sleep associates with adverse chronic kidney disease (CKD) outcomes yet the biological mechanisms underlying this relation remain unclear. One proposed mechanism is via allostatic load, a cumulative biologic measure of stress. Methods:Using data from 5177 Jackson Heart Study participants with sleep measures available, we examined the association of self-reported sleep duration: very short, short, recommended, and long (≤5, 6, 7-8, or ≥9 hours per 24 hours, respectively) and sleep quality (high, moderate, low) with prevalent baseline CKD, and estimated glomerular filtration rate (eGFR) decline and incident CKD at follow-up. CKD was defined as eGFR <60 ml/min per 1.73 m2 or urine albumin-to-creatinine ratio ≥30 mg/g. Models were adjusted for demographics, comorbidities, and kidney function. We further evaluated allostatic load (quantified at baseline using 11 biomarkers from neuroendocrine, metabolic, autonomic, and immune domains) as a mediator of these relations using a process analysis approach. Results:Participants with very short sleep duration (vs. 7-8 hours) had greater odds of prevalent CKD (odds ratio [OR] 1.31, 95% confidence interval [CI] 1.03-1.66). Very short, short, or long sleep duration (vs. 7-8 hours) was not associated with kidney outcomes over a median follow-up of 8 years. Low sleep quality (vs. high) associated with greater odds of prevalent CKD (OR 1.26, 95% CI 1.00-1.60) and 0.18 ml/min per 1.73 m2 (95% CI 0.00-0.36) faster eGFR decline per year. Allostatic load did not mediate the associations of sleep duration or sleep quality with kidney outcomes. Conclusions:Very short sleep duration and low sleep quality were associated with adverse kidney outcomes in this all-black cohort, but allostatic load did not appear to mediate these associations.

S2468-0249(18)30347-4

2468-0249

2468-0249

https://hdl.handle.net/10161/18544

eng

Elsevier BV

Kidney international reports

10.1016/j.ekir.2018.12.005

African Americans

kidney diseases

sleep

sleep deprivation

Evaluation of Allostatic Load as a Mediator of Sleep and Kidney Outcomes in Black Americans.

Journal article

Lunyera, Joseph|0000-0002-9350-320X

Stanifer, John W|0000-0001-6379-300X

Boulware, L Ebony|0000-0002-8650-4212

Diamantidis, Clarissa J|0000-0001-8212-6288

425

433

3

School of Medicine

Duke

Duke Clinical Research Institute

Institutes and Centers

Medicine, Nephrology

Medicine

Clinical Science Departments

Staff

Medicine, General Internal Medicine

Duke Science & Society

Initiatives

Institutes and Provost's Academic Units

Duke Global Health Institute

University Institutes and Centers

Biostatistics & Bioinformatics

Basic Science Departments

Population Health Sciences

Community and Family Medicine

Published

4