Vertebral artery fusiform aneurysm geometry in predicting rupture risk.
Date
2018-10-31
Journal Title
Journal ISSN
Volume Title
Repository Usage Stats
views
downloads
Citation Stats
Attention Stats
Abstract
Cerebral aneurysms affect a significant portion of the adult population worldwide. Despite significant progress, the development of robust techniques to evaluate the risk of aneurysm rupture remains a critical challenge. We hypothesize that vertebral artery fusiform aneurysm (VAFA) morphology may be predictive of rupture risk and can serve as a deciding factor in clinical management. To investigate the VAFA morphology, we use a combination of image analysis and machine learning techniques to study a geometric feature set computed from a depository of 37 (12 ruptured and 25 un-ruptured) aneurysm images. Of the 571 unique features we compute, we distinguish five features for use by our machine learning classification algorithm by an analysis of statistical significance. These machine learning methods achieve state-of-the-art classification performance (81.43 ± 13.08%) for the VAFA morphology, and identify five features (cross-sectional area change of aneurysm, maximum diameter of nearby distal vessel, solidity of aneurysm, maximum curvature of nearby distal vessel, and ratio of curvature between aneurysm and its nearby proximal vessel) as effective predictors of VAFA rupture risk. These results suggest that the geometric features of VAFA morphology may serve as useful non-invasive indicators for the prediction of aneurysm rupture risk in surgical settings.
Type
Department
Description
Provenance
Citation
Permalink
Published Version (Please cite this version)
Publication Info
Zhao, Xiukun, Nathan Gold, Yibin Fang, Shixin Xu, Yongxin Zhang, Jianmin Liu, Arvind Gupta, Huaxiong Huang, et al. (2018). Vertebral artery fusiform aneurysm geometry in predicting rupture risk. Royal Society open science, 5(10). p. 180780. 10.1098/rsos.180780 Retrieved from https://hdl.handle.net/10161/21200.
This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.
Collections
Scholars@Duke

Shixin Xu
Shixin Xu is an Assistant Professor of Mathematics whose research spans several dynamic and interconnected fields. His primary interests include machine learning and data-driven models for disease prediction, multiscale modeling of complex fluids, neurovascular coupling, homogenization theory, and numerical analysis. His current projects reflect a diverse and impactful portfolio:
- Developing predictive models based on image data to identify hemorrhagic transformation in acute ischemic stroke.
- Conducting electrodynamics modeling of saltatory conduction along myelinated axons to understand nerve impulse transmission.
- Engaging in electrochemical modeling to explore the interactions between electric fields and chemical processes.
- Investigating fluid-structure interactions with mass transport and reactions, crucial for understanding physiological and engineering systems.
These projects demonstrate his commitment to addressing complex problems through interdisciplinary approaches that bridge mathematics with biological and physical sciences.
Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.