Fatal respiratory infection due to ST308 VIM-1-producing Pseudomonas aeruginosa in a lung transplant recipient: case report and review of the literature.

Carugati, M

Piazza, A

Peri, AM

Cariani, L

Brilli, M

Girelli, D

Di Carlo, D

Gramegna, A

Pappalettera, M

Comandatore, F

Grasselli, G

Cantù, AP

Arghittu, M

Gori, A

Bandi, C

Blasi, F

Bandera, A

IFALT working group

2020-09-02T08:17:54Z

2020-09-02T08:17:54Z

2020-08-26

2020-09-02T08:17:51Z

BACKGROUND:Data regarding the prevalence of metallo-β-lactamases (MBLs) among Pseudomonas aeruginosa isolates in cystic fibrosis patients are scarce. Furthermore, there is limited knowledge on the effect of MBL production on patient outcomes. Here we describe a fatal respiratory infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient and the results of the subsequent epidemiological investigation. CASE PRESENTATION:P. aeruginosa isolates collected in the index patient and among patients temporally or spatially linked with the index patient were analyzed in terms of antibiotic susceptibility profile and MBL production. Whole-genome sequencing and phylogenetic reconstruction were also performed for all P. aeruginosa isolates producing VIM-type MBLs. A VIM-producing P. aeruginosa strain was identified in a lung biopsy of a lung transplant recipient with cystic fibrosis. The strain was VIM-1-producer and belonged to the ST308. Despite aggressive treatment, the transplant patient succumbed to the pulmonary infection due to the ST308 strain. A VIM-producing P. aeruginosa strain was also collected from the respiratory samples of a different cystic fibrosis patient attending the same cystic fibrosis center. This isolate harbored the blaVIM-2 gene and belonged to the clone ST175. This patient did not experience an adverse outcome. CONCLUSIONS:This is the first description of a fatal infection due to P. aeruginosa producing VIM-type MBLs in a lung transplant recipient. The circulation of P. aeruginosa isolates harboring MBLs pose a substantial risk to the cystic fibrosis population due to the limited therapeutic options available and their spreading potential.

10.1186/s12879-020-05338-3

1471-2334

1471-2334

https://hdl.handle.net/10161/21408

eng

Springer Science and Business Media LLC

BMC infectious diseases

10.1186/s12879-020-05338-3

IFALT working group

Fatal respiratory infection due to ST308 VIM-1-producing Pseudomonas aeruginosa in a lung transplant recipient: case report and review of the literature.

Journal article

Carugati, M|0000-0002-3187-5905

635

1

School of Medicine

Medicine, Infectious Diseases

Duke

Medicine

Clinical Science Departments

Published

20