Complete genome sequences for two talaromyces marneffei clinical isolates from Northern and Southern Vietnam

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2020-01-01

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Abstract

© 2020 Cuomo et al. Talaromyces marneffei is a thermally dimorphic fungus endemic in China and Southeast Asia that causes fatal infections in immunocompromised individuals, particularly in patients with advanced HIV disease. Here, we report the complete genome sequences of two clinical isolates from northern and southern Vietnam.

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10.1128/MRA.01367-19

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Cuomo, Christina A, Terrance Shea, Thu Nguyen, Philip Ashton, John Perfect and Thuy Le (2020). Complete genome sequences for two talaromyces marneffei clinical isolates from Northern and Southern Vietnam. Microbiology Resource Announcements, 9(2). 10.1128/MRA.01367-19 Retrieved from https://hdl.handle.net/10161/21278.

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Scholars@Duke

Perfect

John Robert Perfect

James B. Duke Distinguished Professor of Medicine

Research in my laboratory focuses around several aspects of medical mycology. We are investigating antifungal agents (new and old) in animal models of candida and cryptococcal infections. We have examined clinical correlation of in vitro antifungal susceptibility testing and with in vivo outcome. Our basic science project examines the molecular pathogenesis of cryptococcal infections. We have developed a molecular foundation for C. neoformans, including transformation systems, gene disruptions, differential gene expression screens, and cloning pathogenesis genes. The goal of this work is to use C. neoformans as a model yeast system to identify molecular targets for antifungal drug development. There are a series of clinical trials in fungal infections which are being coordinated through this laboratory and my work also includes a series of antibiotic trials in various aspects of infections. Finally, we have now been awarded a NIH sponsored Mycology Unit for 5 years with 6 senior investigators which is focused on C. neoformans as a pathogenic model system, but will include multiple areas of medical mycology from diagnosis to treatment.

Le

Thuy Le

Associate Professor of Medicine

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