Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Carugati, Manuela

Arif, Sana

Sudan, Debra Lynn

Collins, Bradley Henry

Haney, John Carroll

Schroder, Jacob Niall

Reynolds, John Michael

Lewis, Sarah Stamps

Yarrington, Michael Edwards

Miller, Rachel Ann

Alexander, Barbara Dudley

2022-10-03T10:54:11Z

2022-10-03T10:54:11Z

2022-09

2022-10-03T10:54:10Z

Surgical site infections (SSI) are severe complications of solid organ transplant (SOT). This retrospective study assessed the epidemiology of and outcomes associated with invasive primary SSI (IP-SSI) occurring within 3 months of transplantation in adult SOT recipients at Duke University over a 5-year period (2015-2019). Among 2073 consecutive SOT recipients, 198 IP-SSI were identified. The IP-SSI rate declined over the period (14.4% in 2015 vs. 8.3% in 2019) and was higher among multi-organ compared with single-organ transplants (33.9% vs. 8.1%, p < .01). SOT recipients with IP-SSI had longer hospital stays than patients without SSI (30.0 vs. 17.0 days, p < .01). Transplant hospitalization (9.6% vs. 2.2%, p < .01), 6-month (11.6% vs. 3.3%, p < .01), and 1-year mortality (15.7% vs. 5.8%, p < .01) were higher in SOT recipients with IP-SSI than in those without. While Gram-positive bacteria were the most common pathogens, urogenital Mollicute and atypical Mycobacteria were identified as an unexpected cause of IP-SSI, particularly among lung transplant recipients. The median time to IP-SSI was 24.0 (IQR 13.8-48.3) days, although the time to IP-SSI varied based on organ transplanted and the causative pathogen. IP-SSI is an important and potentially modifiable complication of SOT, associated with prolonged hospitalizations and reduced survival, particularly in the lung transplant population.

1600-6135

1600-6143

https://hdl.handle.net/10161/26020

eng

Elsevier BV

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

10.1111/ajt.17189

clinical research / practice

complication: infectious

infection - mycobacterial: nontuberculous

infection and infectious agents - bacterial

infection and infectious agents - fungal

infectious disease

Epidemiology of surgical site infections after solid organ transplants in the period 2015-2019: A single-center retrospective cohort study.

Journal article

Carugati, Manuela|0000-0002-3187-5905

Sudan, Debra Lynn|0000-0003-4315-4459

Reynolds, John Michael|0000-0003-4766-8852

Yarrington, Michael Edwards|0000-0003-3186-1519

Miller, Rachel Ann|0000-0001-7387-1171

Alexander, Barbara Dudley|0000-0001-5868-0529

Duke

School of Medicine

Clinical Science Departments

Medicine

Pathology

Medicine, Infectious Diseases

Published