Cerebral oxygenation and optimal vascular brain organization.

dc.contributor.author

Hadjistassou, Constantinos

dc.contributor.author

Bejan, Adrian

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Ventikos, Yiannis

dc.coverage.spatial

England

dc.date.accessioned

2017-08-09T16:02:30Z

dc.date.available

2017-08-09T16:02:30Z

dc.date.issued

2015-06-06

dc.description.abstract

The cerebral vascular network has evolved in such a way so as to minimize transport time and energy expenditure. This is accomplished by a subtle combination of the optimal arrangement of arteries, arterioles and capillaries and the transport mechanisms of convection and diffusion. Elucidating the interaction between cerebral vascular architectonics and the latter physical mechanisms can catalyse progress in treating cerebral pathologies such as stroke, brain tumours, dementia and targeted drug delivery. Here, we show that brain microvascular organization is predicated on commensurate intracapillary oxygen convection and parenchymal diffusion times. Cross-species grey matter results for the rat, cat, rabbit and human reveal very good correlation between the cerebral capillary and tissue mean axial oxygen convective and diffusion time intervals. These findings agree with the constructal principle.

dc.identifier

https://www.ncbi.nlm.nih.gov/pubmed/25972435

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rsif.2015.0245

dc.identifier.eissn

1742-5662

dc.identifier.uri

https://hdl.handle.net/10161/15208

dc.language

eng

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The Royal Society

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J R Soc Interface

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10.1098/rsif.2015.0245

dc.subject

diffusion and convection time

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mammalian vascular architecture

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optimal

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oxygen

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Animals

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Cats

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Cerebrovascular Circulation

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Gray Matter

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Humans

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Models, Cardiovascular

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Oxygen

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Rabbits

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Rats

dc.title

Cerebral oxygenation and optimal vascular brain organization.

dc.type

Journal article

duke.contributor.orcid

Bejan, Adrian|0000-0002-2419-2698

pubs.author-url

https://www.ncbi.nlm.nih.gov/pubmed/25972435

pubs.issue

107

pubs.organisational-group

Duke

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Mechanical Engineering and Materials Science

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Pratt School of Engineering

pubs.publication-status

Published

pubs.volume

12

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