Hürthle cell carcinoma: current perspectives.

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Hürthle cell carcinoma (HCC) can present either as a minimally invasive or as a widely invasive tumor. HCC generally has a more aggressive clinical behavior compared with the other differentiated thyroid cancers, and it is associated with a higher rate of distant metastases. Minimally invasive HCC demonstrates much less aggressive behavior; lesions <4 cm can be treated with thyroid lobectomy alone, and without radioactive iodine (RAI). HCC has been observed to be less iodine-avid compared with other differentiated thyroid cancers; however, recent data have demonstrated improved survival with RAI use in patients with HCC >2 cm and those with nodal and distant metastases. Patients with localized iodine-resistant disease who are not candidates for a wait-and-watch approach can be treated with localized therapies. Systemic therapy is reserved for patients with progressive, widely metastatic HCC.





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Ahmadi, Sara, Michael Stang, Xiaoyin Sara Jiang and Julie Ann Sosa (2016). Hürthle cell carcinoma: current perspectives. Onco Targets Ther, 9. pp. 6873–6884. 10.2147/OTT.S119980 Retrieved from https://hdl.handle.net/10161/15141.

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Michael Tracey Stang

Associate Professor of Surgery

Xiaoyin Jiang

Professor of Pathology

I am a pathologist specializing in cytopathology and surgical pathology. I diagnose diseases through integrating clinical history and studying patient samples under the microscope. As a cytopathologist, I perform fine needle aspiration biopsies in our clinic. I serve as Chief of the Head and Neck Service, and Director of the Duke Pathology Communications Group.
My research interests focus on the pathology of the head and neck and endocrine systems, with particular interest in thyroid nodules and neoplasia, and ultrasound-guided FNA. I work with a multidisciplinary team to improve our understanding of disease. I also focus on novel applications of social media for physicians and medical education.

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