Optimizing donor selection for public cord blood banking: influence of maternal, infant, and collection characteristics on cord blood unit quality.

dc.contributor.author

Page, Kristin M

dc.contributor.author

Mendizabal, Adam

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Betz-Stablein, Brigid

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Wease, Stephen

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Shoulars, Kevin

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Gentry, Tracy

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Prasad, Vinod K

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Sun, Jessica

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Carter, Shelly

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Balber, Andrew E

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Kurtzberg, Joanne

dc.date.accessioned

2022-03-23T20:38:30Z

dc.date.available

2022-03-23T20:38:30Z

dc.date.issued

2014-02

dc.date.updated

2022-03-23T20:38:30Z

dc.description.abstract

Background

Banked unrelated donor umbilical cord blood (CB) has improved access to hematopoietic stem cell transplantation for patients without a suitably matched donor. In a resource-limited environment, ensuring that the public inventory is enriched with high-quality cord blood units (CBUs) addressing the needs of a diverse group of patients is a priority. Identification of donor characteristics correlating with higher CBU quality could guide operational strategies to increase the yield of banked high-quality CBUs.

Study design and methods

Characteristics of 5267 CBUs donated to the Carolinas Cord Blood Bank, a public bank participating in the National Cord Blood Inventory, were retrospectively analyzed. Eligible CBUs, collected by trained personnel, were processed using standard procedures. Routine quality and potency metrics (postprocessing total nucleated cell count [post-TNCC], CD34+, colony-forming units [CFUs]) were correlated with maternal, infant, and collection characteristics.

Results

High-quality CBUs were defined as those with higher post-TNCC (>1.25 × 10(9)) with CD34+ and CFUs in the upper quartile. Factors associated with higher CD34+ or CFU content included a shorter interval from collection to processing (<10 hr), younger gestational age (34-37 weeks; CD34+ and CFUs), Caucasian race, higher birthweight (>3500 g), and larger collection volumes (>80 mL).

Conclusions

We describe characteristics identifying high-quality CBUs, which can be used to inform strategies for CBU collection for public banks. Efforts should be made to prioritize collections from larger babies born before 38 weeks of gestation. CBUs should be rapidly transported to the processing laboratory. The lower quality of CBUs from non-Caucasian donors highlights the challenges of building a racially diverse public CB inventory.
dc.identifier.issn

0041-1132

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1537-2995

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https://hdl.handle.net/10161/24695

dc.language

eng

dc.publisher

Wiley

dc.relation.ispartof

Transfusion

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10.1111/trf.12257

dc.subject

Fetal Blood

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Humans

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Hematopoietic Stem Cell Transplantation

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Multivariate Analysis

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Retrospective Studies

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Equipment and Supplies

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Gestational Age

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Adolescent

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Adult

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Middle Aged

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Infant, Newborn

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Ethnic Groups

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Blood Donors

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Academic Medical Centers

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Blood Banks

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North Carolina

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Female

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Male

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Young Adult

dc.title

Optimizing donor selection for public cord blood banking: influence of maternal, infant, and collection characteristics on cord blood unit quality.

dc.type

Journal article

duke.contributor.orcid

Page, Kristin M|0000-0001-9670-8828

duke.contributor.orcid

Sun, Jessica|0000-0001-8085-1013

duke.contributor.orcid

Kurtzberg, Joanne|0000-0002-3370-0703

pubs.begin-page

340

pubs.end-page

352

pubs.issue

2

pubs.organisational-group

Duke

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School of Medicine

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Faculty

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Clinical Science Departments

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Institutes and Centers

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Pathology

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Pediatrics

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Pediatrics, Hematology-Oncology

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Duke Cancer Institute

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Institutes and Provost's Academic Units

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Initiatives

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Duke Innovation & Entrepreneurship

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Pediatrics, Transplant and Cellular Therapy

pubs.publication-status

Published

pubs.volume

54

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