Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening

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2018-01-11

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Abstract

Single-cell screening is used to sort a stream of cells into clusters (or types) based on pre-specified biomarkers, thus supporting type-driven biochemical analysis. Reconfigurable flowbased microfluidic biochips (RFBs) can be utilized to screen hundreds of heterogeneous cells within a few minutes, but they are overburdened with the control of a large number of valves. To address this problem, we present a pin-constrained RFB design methodology for single-cell screening. The proposed design is analyzed using computational fluid dynamics simulations, mapped to an RC-lumped model, and combined with intervalve connectivity information to construct a high-level synthesis framework, referred to as Sortex. Simulation results show that Sortex significantly reduces the number of control pins and fulfills the timing requirements of single-cell screening.

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Ibrahim, M, A Sridhar, K Chakrabarty and U Schlichtmann (2018). Synthesis of Reconfigurable Flow-Based Biochips for Scalable Single-Cell Screening. Retrieved from https://hdl.handle.net/10161/15989.


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