Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Wang, Zhongqiu

Sturgis, Erich M

Zhang, Fenghua

Lei, Dapeng

Liu, Zhensheng

Xu, Li

Song, Xicheng

Wei, Qingyi

Li, Guojun

2019-02-01T15:26:39Z

2019-02-01T15:26:39Z

2012-03-26

2019-02-01T15:26:37Z

Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms modifies risk of second primary malignancy (SPM) in patients with index squamous cell carcinoma of head and neck (SCCHN).A cohort of 1,292 patients with index SCCHN was recruited between May 1995 and January 2007 at the M.D. Anderson Cancer Center and followed for SPM occurrence. Patients were genotyped for the three polymorphisms. A log-rank test and Cox proportional hazards models were used to compare SPM-free survival and SPM risk.We found that patients with p27 109 TG/GG, p21 98 CA/AA and p21 70 CT/TT variant genotypes had a worse SPM-free survival and an increased SPM risk than those with the corresponding p27109 TT, p21 98 CC, and p21 70 CC common genotypes, respectively. After combining the three polymorphisms, there was a trend for significantly increased SPM risk with increasing number of the variant genotypes (Ptrend = 0.0002). Moreover, patients with the variant genotypes had an approximately 2.4-fold significantly increased risk for SPM compared with those with no variant genotypes (HR, 2.4, 95% CI, 1.6-3.6).These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.

1476-4598-11-17

1476-4598

1476-4598

https://hdl.handle.net/10161/18020

eng

Springer Science and Business Media LLC

Molecular cancer

10.1186/1476-4598-11-17

Humans

Carcinoma, Squamous Cell

Head and Neck Neoplasms

Neoplasms, Second Primary

Genetic Predisposition to Disease

Genotype

Polymorphism, Genetic

Middle Aged

Female

Male

Cyclin-Dependent Kinase Inhibitor p21

Cyclin-Dependent Kinase Inhibitor p27

Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Journal article

Wei, Qingyi|0000-0002-3845-9445|0000-0003-4115-4439

17

1

Staff

Duke

School of Medicine

Duke Cancer Institute

Institutes and Centers

Population Health Sciences

Basic Science Departments

Medicine, Medical Oncology

Medicine

Clinical Science Departments

Published

11