Primate malarias as a model for cross-species parasite transmission.

Loading...
Thumbnail Image

Date

2022-01

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

12
views
19
downloads

Citation Stats

Abstract

Parasites regularly switch into new host species, representing a disease burden and conservation risk to the hosts. The distribution of these parasites also gives insight into characteristics of ecological networks and genetic mechanisms of host-parasite interactions. Some parasites are shared across many species, whereas others tend to be restricted to hosts from a single species. Understanding the mechanisms producing this distribution of host specificity can enable more effective interventions and potentially identify genetic targets for vaccines or therapies. As ecological connections between human and local animal populations increase, the risk to human and wildlife health from novel parasites also increases. Which of these parasites will fizzle out and which have the potential to become widespread in humans? We consider the case of primate malarias, caused by Plasmodium parasites, to investigate the interacting ecological and evolutionary mechanisms that put human and nonhuman primates at risk for infection. Plasmodium host switching from nonhuman primates to humans led to ancient introductions of the most common malaria-causing agents in humans today, and new parasite switching is a growing threat, especially in Asia and South America. Based on a wild host-Plasmodium occurrence database, we highlight geographic areas of concern and potential areas to target further sampling. We also discuss methodological developments that will facilitate clinical and field-based interventions to improve human and wildlife health based on this eco-evolutionary perspective.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.7554/elife.69628

Publication Info

Voinson, Marina, Charles L Nunn and Amy Goldberg (2022). Primate malarias as a model for cross-species parasite transmission. eLife, 11. p. e69628. 10.7554/elife.69628 Retrieved from https://hdl.handle.net/10161/26412.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.

Scholars@Duke

Nunn

Charles L Nunn

Gosnell Family Professor in Global Health
Goldberg

Amy Goldberg

Assistant Professor of Evolutionary Anthropology

See website: www.goldberglab.org


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.