Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management.

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2022-10

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Abstract

A positive follow-up blood culture for methicillin-resistant Staphylococcus aureus (MRSA) while on seemingly appropriate therapy is a common and ominous development. However, the definition and management of persistent MRSA bacteremia is unstandardized. In this Opinion Paper, we identify the presence of bacteremia for > 1 calendar day as a "worry point" that should trigger an intensive diagnostic evaluation to identify metastatic infection sites. Next, we define the duration of MRSA bacteremia that likely constitutes antibiotic failure and outline a potential management algorithm for such patients. Finally, we propose pragmatic clinical trial designs to test treatment strategies for persistent MRSA bacteremia.

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Journal article

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Humans, Bacteremia, Staphylococcal Infections, Anti-Bacterial Agents, Methicillin-Resistant Staphylococcus aureus, Pragmatic Clinical Trials as Topic

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https://hdl.handle.net/10161/29594

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https://creativecommons.org/licenses/by-nc/4.0

Published Version (Please cite this version)

10.1093/cid/ciac364

Publication Info

Holland, Thomas L, Arnold S Bayer and Vance G Fowler (2022). Persistent Methicilin-Resistant Staphylococcus aureus Bacteremia: Resetting the Clock for Optimal Management. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 75(9). pp. 1668–1674. 10.1093/cid/ciac364 Retrieved from https://hdl.handle.net/10161/29594.

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