The impact of caspase-12 on susceptibility to candidemia.
dc.contributor.author | Rosentul, DC | |
dc.contributor.author | Plantinga, TS | |
dc.contributor.author | Scott, WK | |
dc.contributor.author | Alexander, BD | |
dc.contributor.author | van de Geer, NMD | |
dc.contributor.author | Perfect, JR | |
dc.contributor.author | Kullberg, BJ | |
dc.contributor.author | Johnson, MD | |
dc.contributor.author | Netea, MG | |
dc.date.accessioned | 2022-10-03T11:11:23Z | |
dc.date.available | 2022-10-03T11:11:23Z | |
dc.date.issued | 2012-03 | |
dc.date.updated | 2022-10-03T11:11:23Z | |
dc.description.abstract | Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. In populations of African descent, CASPASE-12 is either functional or non-functional. Here, we have assessed the frequencies of both CASPASE-12 alleles in an African-American Candida sepsis patients cohort compared to uninfected patients with similar predisposing factors. African-American Candida sepsis patients (n = 93) and non-infected African-American patients (n = 88) were genotyped for the CASPASE-12 genotype. Serum cytokine concentrations of IL-6, IL-8, and IFNγ were measured in the serum of infected patients. Statistical comparisons were performed in order to assess the effect of the CASPASE-12 genotype on susceptibility to candidemia and on serum cytokine concentrations. Our findings demonstrate that CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients. | |
dc.identifier.issn | 0934-9723 | |
dc.identifier.issn | 1435-4373 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Springer Science and Business Media LLC | |
dc.relation.ispartof | European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | |
dc.relation.isversionof | 10.1007/s10096-011-1307-x | |
dc.subject | Humans | |
dc.subject | Candida | |
dc.subject | Sepsis | |
dc.subject | Disease Susceptibility | |
dc.subject | Interleukin-8 | |
dc.subject | Interleukin-6 | |
dc.subject | Genotype | |
dc.subject | Middle Aged | |
dc.subject | African Americans | |
dc.subject | Female | |
dc.subject | Male | |
dc.subject | Caspase 12 | |
dc.subject | Interferon-gamma | |
dc.subject | Genetic Variation | |
dc.subject | Candidemia | |
dc.title | The impact of caspase-12 on susceptibility to candidemia. | |
dc.type | Journal article | |
duke.contributor.orcid | Alexander, BD|0000-0001-5868-0529 | |
duke.contributor.orcid | Perfect, JR|0000-0002-6606-9460|0000-0003-3465-5518 | |
duke.contributor.orcid | Johnson, MD|0000-0002-6606-9460 | |
pubs.begin-page | 277 | |
pubs.end-page | 280 | |
pubs.issue | 3 | |
pubs.organisational-group | Duke | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | Basic Science Departments | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Molecular Genetics and Microbiology | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.publication-status | Published | |
pubs.volume | 31 |
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