The impact of caspase-12 on susceptibility to candidemia.

dc.contributor.author

Rosentul, DC

dc.contributor.author

Plantinga, TS

dc.contributor.author

Scott, WK

dc.contributor.author

Alexander, BD

dc.contributor.author

van de Geer, NMD

dc.contributor.author

Perfect, JR

dc.contributor.author

Kullberg, BJ

dc.contributor.author

Johnson, MD

dc.contributor.author

Netea, MG

dc.date.accessioned

2022-10-03T11:11:23Z

dc.date.available

2022-10-03T11:11:23Z

dc.date.issued

2012-03

dc.date.updated

2022-10-03T11:11:23Z

dc.description.abstract

Candida is one of the leading causes of sepsis, and an effective host immune response to Candida critically depends on the cytokines IL-1β and IL-18, which need caspase-1 cleavage to become bioactive. Caspase-12 has been suggested to inhibit caspase-1 activation and has been implicated as a susceptibility factor for bacterial sepsis. In populations of African descent, CASPASE-12 is either functional or non-functional. Here, we have assessed the frequencies of both CASPASE-12 alleles in an African-American Candida sepsis patients cohort compared to uninfected patients with similar predisposing factors. African-American Candida sepsis patients (n = 93) and non-infected African-American patients (n = 88) were genotyped for the CASPASE-12 genotype. Serum cytokine concentrations of IL-6, IL-8, and IFNγ were measured in the serum of infected patients. Statistical comparisons were performed in order to assess the effect of the CASPASE-12 genotype on susceptibility to candidemia and on serum cytokine concentrations. Our findings demonstrate that CASPASE-12 does not influence the susceptibility to Candida sepsis, nor has any effect on the serum cytokine concentrations in Candida sepsis patients during the course of infection. Although the functional CASPASE-12 allele has been suggested to increase susceptibility to bacterial sepsis, this could not be confirmed in our larger cohort of fungal sepsis patients.

dc.identifier.issn

0934-9723

dc.identifier.issn

1435-4373

dc.identifier.uri

https://hdl.handle.net/10161/26035

dc.language

eng

dc.publisher

Springer Science and Business Media LLC

dc.relation.ispartof

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

dc.relation.isversionof

10.1007/s10096-011-1307-x

dc.subject

Humans

dc.subject

Candida

dc.subject

Sepsis

dc.subject

Disease Susceptibility

dc.subject

Interleukin-8

dc.subject

Interleukin-6

dc.subject

Genotype

dc.subject

Middle Aged

dc.subject

African Americans

dc.subject

Female

dc.subject

Male

dc.subject

Caspase 12

dc.subject

Interferon-gamma

dc.subject

Genetic Variation

dc.subject

Candidemia

dc.title

The impact of caspase-12 on susceptibility to candidemia.

dc.type

Journal article

duke.contributor.orcid

Alexander, BD|0000-0001-5868-0529

duke.contributor.orcid

Perfect, JR|0000-0002-6606-9460|0000-0003-3465-5518

duke.contributor.orcid

Johnson, MD|0000-0002-6606-9460

pubs.begin-page

277

pubs.end-page

280

pubs.issue

3

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

pubs.organisational-group

Basic Science Departments

pubs.organisational-group

Clinical Science Departments

pubs.organisational-group

Molecular Genetics and Microbiology

pubs.organisational-group

Medicine

pubs.organisational-group

Pathology

pubs.organisational-group

Medicine, Infectious Diseases

pubs.publication-status

Published

pubs.volume

31

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