Right coronary wall CMR in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium.

Terashima, Masahiro

Nguyen, Patricia K

Rubin, Geoffrey D

Meyer, Craig H

Shimakawa, Ann

Nishimura, Dwight G

Ehara, Shoichi

Iribarren, Carlos

Courtney, Brian K

Go, Alan S

Hlatky, Mark A

Fortmann, Stephen P

McConnell, Michael V

England

2017-07-03T14:58:03Z

2017-07-03T14:58:03Z

2010-12-30

BACKGROUND: Coronary wall cardiovascular magnetic resonance (CMR) is a promising noninvasive approach to assess subclinical atherosclerosis, but data are limited in subjects over 60 years old, who are at increased risk. The purpose of the study was to evaluate coronary wall CMR in an asymptomatic older cohort. RESULTS: Cross-sectional images of the proximal right coronary artery (RCA) were acquired using spiral black-blood coronary CMR (0.7 mm resolution) in 223 older, community-based patients without a history of cardiovascular disease (age 60-72 years old, 38% female). Coronary measurements (total vessel area, lumen area, wall area, and wall thickness) had small intra- and inter-observer variabilities (r = 0.93~0.99, all p < 0.0001), though one-third of these older subjects had suboptimal image quality. Increased coronary wall thickness correlated with increased coronary vessel area (p < 0.0001), consistent with positive remodeling. On multivariate analysis, type 2 diabetes was the only risk factor associated with increased coronary wall area and thickness (p = 0.03 and p = 0.007, respectively). Coronary wall CMR measures were also associated with coronary calcification (p = 0.01-0.03). CONCLUSIONS: Right coronary wall CMR in asymptomatic older subjects showed increased coronary atherosclerosis in subjects with type 2 diabetes as well as coronary calcification. Coronary wall CMR may contribute to the noninvasive assessment of subclinical coronary atherosclerosis in older, at-risk patient groups.

https://www.ncbi.nlm.nih.gov/pubmed/21192815

1532-429X-12-75

1532-429X

https://hdl.handle.net/10161/14975

eng

Springer Science and Business Media LLC

J Cardiovasc Magn Reson

10.1186/1532-429X-12-75

Age Factors

Aged

Asymptomatic Diseases

Calcinosis

California

Chi-Square Distribution

Cohort Studies

Coronary Artery Disease

Diabetes Mellitus, Type 2

Female

Humans

Linear Models

Magnetic Resonance Imaging

Male

Middle Aged

Observer Variation

Predictive Value of Tests

Reproducibility of Results

Risk Assessment

Risk Factors

Right coronary wall CMR in the older asymptomatic advance cohort: positive remodeling and associations with type 2 diabetes and coronary calcium.

Journal article

Rubin, Geoffrey D|0000-0002-3820-2500

https://www.ncbi.nlm.nih.gov/pubmed/21192815

75

Clinical Science Departments

Duke

Radiology

Radiology, Cardiothoracic Imaging

School of Medicine

Published online

12