GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China.
| dc.contributor.author | Zeng, Y | |
| dc.contributor.author | Chen, H | |
| dc.contributor.author | Ni, T | |
| dc.contributor.author | Ruan, R | |
| dc.contributor.author | Feng, L | |
| dc.contributor.author | Nie, C | |
| dc.contributor.author | Cheng, L | |
| dc.contributor.author | Li, Y | |
| dc.contributor.author | Tao, W | |
| dc.contributor.author | Gu, J | |
| dc.contributor.author | Land, KC | |
| dc.contributor.author | Yashin, A | |
| dc.contributor.author | Tan, Q | |
| dc.contributor.author | Yang, Z | |
| dc.contributor.author | Bolund, L | |
| dc.contributor.author | Yang, H | |
| dc.contributor.author | Hauser, E | |
| dc.contributor.author | Willcox, DC | |
| dc.contributor.author | Willcox, BJ | |
| dc.contributor.author | Tian, X | |
| dc.contributor.author | Vaupel, JW | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2017-06-01T19:18:18Z | |
| dc.date.available | 2017-06-01T19:18:18Z | |
| dc.date.issued | 2015-04 | |
| dc.description.abstract | Logistic regression analysis based on data from 822 Han Chinese oldest old aged 92+ demonstrated that interactions between carrying FOXO1A-266 or FOXO3-310 or FOXO3-292 and tea drinking at around age 60 or at present time were significantly associated with lower risk of cognitive disability at advanced ages. Associations between tea drinking and reduced cognitive disability were much stronger among carriers of the genotypes of FOXO1A-266 or FOXO3-310 or FOXO3-292 compared with noncarriers, and it was reconfirmed by analysis of three-way interactions across FOXO genotypes, tea drinking at around age 60, and at present time. Based on prior findings from animal and human cell models, we postulate that intake of tea compounds may activate FOXO gene expression, which in turn may positively affect cognitive function in the oldest old population. Our empirical findings imply that the health benefits of particular nutritional interventions, including tea drinking, may, in part, depend upon individual genetic profiles. | |
| dc.identifier | ||
| dc.identifier | glu060 | |
| dc.identifier.eissn | 1758-535X | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | J Gerontol A Biol Sci Med Sci | |
| dc.relation.isversionof | 10.1093/gerona/glu060 | |
| dc.subject | Cognitive disability | |
| dc.subject | FOXO genotypes | |
| dc.subject | GxE interactions | |
| dc.subject | Oldest old. | |
| dc.subject | Tea drinking | |
| dc.subject | Aged, 80 and over | |
| dc.subject | Aging | |
| dc.subject | Alleles | |
| dc.subject | Asian Continental Ancestry Group | |
| dc.subject | China | |
| dc.subject | Cognition | |
| dc.subject | Cognition Disorders | |
| dc.subject | Drinking Behavior | |
| dc.subject | Evidence-Based Medicine | |
| dc.subject | Female | |
| dc.subject | Forkhead Box Protein O1 | |
| dc.subject | Forkhead Box Protein O3 | |
| dc.subject | Forkhead Transcription Factors | |
| dc.subject | Gene Expression | |
| dc.subject | Genotype | |
| dc.subject | Humans | |
| dc.subject | Longitudinal Studies | |
| dc.subject | Male | |
| dc.subject | Phenotype | |
| dc.subject | Risk Factors | |
| dc.subject | Surveys and Questionnaires | |
| dc.subject | Tea | |
| dc.title | GxE interactions between FOXO genotypes and drinking tea are significantly associated with prevention of cognitive decline in advanced age in China. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Land, KC|0000-0002-9551-7314 | |
| duke.contributor.orcid | Hauser, E|0000-0003-0367-9189 | |
| pubs.author-url | ||
| pubs.begin-page | 426 | |
| pubs.end-page | 433 | |
| pubs.issue | 4 | |
| pubs.organisational-group | Basic Science Departments | |
| pubs.organisational-group | Biostatistics & Bioinformatics | |
| pubs.organisational-group | Center for Population Health & Aging | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Duke Cancer Institute | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Duke Population Research Center | |
| pubs.organisational-group | Duke Population Research Institute | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Institutes and Provost's Academic Units | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Geriatrics | |
| pubs.organisational-group | Sanford School of Public Policy | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Social Science Research Institute | |
| pubs.organisational-group | Sociology | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.organisational-group | University Institutes and Centers | |
| pubs.publication-status | Published | |
| pubs.volume | 70 |
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