Coronal plane spinal malalignment and Parkinson's disease: prevalence and associations with disease severity.

dc.contributor.author

Choi, Hong June

dc.contributor.author

Smith, Justin S

dc.contributor.author

Shaffrey, Christopher I

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Lafage, Virginie C

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Schwab, Frank J

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Ames, Christopher P

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Matsumoto, Morio

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Baik, Jong Sam

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Ha, Yoon

dc.date.accessioned

2023-07-20T19:30:30Z

dc.date.available

2023-07-20T19:30:30Z

dc.date.issued

2015-01

dc.date.updated

2023-07-20T19:30:12Z

dc.description.abstract

Background context

Parkinson's disease (PD) is a progressive degenerative disorder of the central nervous system. Patients with PD often present with abnormal posturing.

Purpose

To investigate coronal plane deformities in patients with PD, and to evaluate the correlation between clinical features, coronal parameters related to spine alignment, and disease severity.

Study design

A cross-sectional study.

Patient sample

Eighty-nine patients with PD and 89 controls were included.

Outcome measures

A medical history was collected from the medical records.

Methods

This study was a prospective assessment of consecutive patients with PD. Clinical and demographic parameters were collected from medical records and outpatient interviews. Full-length standing anteroposterior and lateral spine radiographs were used to assess the spinal parameters. The threshold for scoliosis was set at a 10° Cobb angle, and the curve type was classified using Schwab classification.

Results

A total of 178 patients (89 in PD and 89 in control groups) were included. Scoliosis was identified in 27 patients (30%) and 22 controls (p=.502). However, coronal imbalance was more common in patients with PD than in controls (11 vs. 0 patients, p=.001). Scoliosis was more common in women than in men (male:female=8:19, p=.04). Back pain was more common in patients with scoliosis than in those without scoliosis (14 of 27 vs. 17 of 62, p=.036). Schwab Type IV (thoracolumbar major) was the most common type of scoliosis in patients with PD and Type V (lumbar major) was the most common type in controls. With adjustment for patient age and gender, multiple linear regression analysis revealed that severity of PD (Unified Parkinson's Disease Rating Scale, p=.037) and magnitude of global coronal malalignment (p=.003) were associated with the scoliosis Cobb angle (p=.037, B=0.139). Direction of scoliosis and side of global coronal malalignment were not significantly correlated with the laterality of predominant PD symptoms (p>.05).

Conclusions

Global coronal malalignment is more prevalent in patients with PD than in controls. Greater severity of PD was significantly associated with greater magnitude of scoliosis Cobb angle, even after adjusting for the effects of patient age and gender. However, direction of scoliosis and side of global coronal malalignment were not significantly associated with the dominant laterality of PD symptoms.
dc.identifier

S1529-9430(14)00673-1

dc.identifier.issn

1529-9430

dc.identifier.issn

1878-1632

dc.identifier.uri

https://hdl.handle.net/10161/28517

dc.language

eng

dc.publisher

Elsevier BV

dc.relation.ispartof

The spine journal : official journal of the North American Spine Society

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10.1016/j.spinee.2014.07.004

dc.subject

Spine

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Humans

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Scoliosis

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Parkinson Disease

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Radiography

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Severity of Illness Index

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Prevalence

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Prospective Studies

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Cross-Sectional Studies

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Age Factors

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Sex Factors

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Posture

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Aged

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Aged, 80 and over

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Middle Aged

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Female

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Male

dc.title

Coronal plane spinal malalignment and Parkinson's disease: prevalence and associations with disease severity.

dc.type

Journal article

duke.contributor.orcid

Shaffrey, Christopher I|0000-0001-9760-8386

pubs.begin-page

115

pubs.end-page

121

pubs.issue

1

pubs.organisational-group

Duke

pubs.organisational-group

School of Medicine

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Clinical Science Departments

pubs.organisational-group

Orthopaedic Surgery

pubs.organisational-group

Neurosurgery

pubs.publication-status

Published

pubs.volume

15

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