Cytokine profiles of preterm neonates with fungal and bacterial sepsis.

Sood, Beena G

Shankaran, Seetha

Schelonka, Robert L

Saha, Shampa

Benjamin, Danny K

Sánchez, Pablo J

Adams-Chapman, Ira

Stoll, Barbara J

Thorsen, Poul

Skogstrand, Kristin

Ehrenkranz, Richard A

Hougaard, David M

Goldberg, Ronald N

Tyson, Jon E

Das, Abhik

Higgins, Rosemary D

Carlo, Waldemar A

Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network

United States

2016-12-05T18:43:31Z

2012-08

BACKGROUND: Information on cytokine profiles in fungal sepsis (FS), an important cause of mortality in extremely low birthweight (ELBW) infants, is lacking. We hypothesized that cytokine profiles in the first 21 d of life in ELBW infants with FS differ from those with bacterial sepsis (BS) or no sepsis (NS). METHODS: In a secondary analysis of the National Institute of Child Health and Human Development Cytokine study, three groups were defined-FS (≥1 episode of FS), BS (≥1 episode of BS without FS), and NS. Association between 11 cytokines assayed in dried blood spots obtained on days 0-1, 3 ± 1, 7 ± 2, 14 ± 3, and 21 ± 3 and sepsis group was explored. RESULTS: Of 1,066 infants, 89 had FS and 368 had BS. As compared with BS, FS was more likely to be associated with lower birthweight, vaginal delivery, patent ductus arteriosus, postnatal steroids, multiple central lines, longer respiratory support and hospital stay, and higher mortality (P < 0.05). Analyses controlling for covariates showed significant group differences over time for interferon-γ (IFN-γ), interleukin (IL)-10, IL-18, transforming growth factor-β (TGF-β), and tumor necrosis factor-α (TNF-α) (P < 0.05). CONCLUSION: Significant differences in profiles for IFN-γ, IL-10, IL-18, TGF-β, and TNF-α in FS, BS, or NS in this hypothesis-generating secondary study require validation in rigorously designed prospective studies and may have implications for diagnosis and treatment.

http://www.ncbi.nlm.nih.gov/pubmed/22562288

pr201256

1530-0447

https://hdl.handle.net/10161/13145

eng

Springer Science and Business Media LLC

Pediatr Res

10.1038/pr.2012.56

Area Under Curve

Bacteremia

Case-Control Studies

Cytokines

Dried Blood Spot Testing

Fungemia

Humans

Infant, Extremely Low Birth Weight

Infant, Newborn

Infant, Premature

Interferon-gamma

Interleukin-10

Interleukin-18

Models, Statistical

ROC Curve

Transforming Growth Factor beta

Tumor Necrosis Factor-alpha

Cytokine profiles of preterm neonates with fungal and bacterial sepsis.

Journal article

Benjamin, Danny K|0000-0002-0764-8585

http://www.ncbi.nlm.nih.gov/pubmed/22562288

212

220

2

Clinical Science Departments

Duke

Duke Clinical Research Institute

Institutes and Centers

Obstetrics and Gynecology

Pediatrics

Pediatrics, Infectious Diseases

Pediatrics, Neonatology

School of Medicine

School of Nursing

School of Nursing - Secondary Group

Published

72