Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania.
dc.contributor.author | Mavura, Daudi R | |
dc.contributor.author | Masenga, E John | |
dc.contributor.author | Minja, Eli | |
dc.contributor.author | Grossmann, Henning | |
dc.contributor.author | Crump, John A | |
dc.contributor.author | Bartlett, John A | |
dc.coverage.spatial | England | |
dc.date.accessioned | 2017-03-02T19:06:46Z | |
dc.date.available | 2017-03-02T19:06:46Z | |
dc.date.issued | 2015-01 | |
dc.description.abstract | Abnormal skin findings are identified in over 90% of human immunodeficiency virus (HIV)-infected persons globally. A prospective cohort study of HIV-infected patients with skin complaints commencing antiretroviral therapy (ART) in northern Tanzania was undertaken. Consecutive HIV-infected subjects presenting with skin complaints, who met criteria for ART initiation, were recruited at a Tanzanian Regional Dermatology Training Center. A single dermatologist evaluated all subjects; baseline skin biopsies were performed, and CD4(+) cell counts and plasma HIV RNA levels were measured. All subjects received a fixed-dose combination of stavudine, lamivudine, and nevirapine. A total of 100 subjects were enrolled; 86 subjects completed six months of follow-up. Median baseline CD4(+) cell counts and plasma HIV RNA levels were 120 cells/μl and 5.2 log10 copies/ml. The most common dermatologic condition was papular pruritic eruption (47%). The median baseline score on the Burn Scale was 38%. After six months, 10 subjects had achieved the complete resolution of skin abnormalities. In those without complete resolution, the median Burn Scale score improved to 7%. Five patients developed new eruptions by month 3, which in two cases were attributed to drug reactions. In the 86 subjects remaining on ART after six months, the median CD4(+) cell count had increased to 474 cells/μl, and plasma HIV RNA levels were <400 copies/ml in 85 (99%) subjects. Patients with HIV infection with skin complaints experienced marked clinical improvements following ART initiation. | |
dc.identifier | ||
dc.identifier.eissn | 1365-4632 | |
dc.identifier.uri | ||
dc.language | eng | |
dc.publisher | Wiley | |
dc.relation.ispartof | Int J Dermatol | |
dc.relation.isversionof | 10.1111/ijd.12563 | |
dc.subject | Adolescent | |
dc.subject | Adult | |
dc.subject | Aged | |
dc.subject | Anti-HIV Agents | |
dc.subject | CD4 Lymphocyte Count | |
dc.subject | Female | |
dc.subject | HIV | |
dc.subject | HIV Infections | |
dc.subject | Humans | |
dc.subject | Lamivudine | |
dc.subject | Male | |
dc.subject | Middle Aged | |
dc.subject | Nevirapine | |
dc.subject | Prospective Studies | |
dc.subject | RNA, Viral | |
dc.subject | Severity of Illness Index | |
dc.subject | Skin Diseases | |
dc.subject | Stavudine | |
dc.subject | Tanzania | |
dc.subject | Young Adult | |
dc.title | Initiation of antiretroviral therapy in HIV-infected adults with skin complaints in northern Tanzania. | |
dc.type | Journal article | |
duke.contributor.orcid | Crump, John A|0000-0002-4529-102X | |
pubs.author-url | ||
pubs.begin-page | 68 | |
pubs.end-page | 73 | |
pubs.issue | 1 | |
pubs.organisational-group | Clinical Science Departments | |
pubs.organisational-group | Duke | |
pubs.organisational-group | Duke Cancer Institute | |
pubs.organisational-group | Duke Science & Society | |
pubs.organisational-group | Global Health Institute | |
pubs.organisational-group | Initiatives | |
pubs.organisational-group | Institutes and Centers | |
pubs.organisational-group | Institutes and Provost's Academic Units | |
pubs.organisational-group | Medicine | |
pubs.organisational-group | Medicine, Infectious Diseases | |
pubs.organisational-group | Pathology | |
pubs.organisational-group | School of Medicine | |
pubs.organisational-group | School of Nursing | |
pubs.organisational-group | School of Nursing - Secondary Group | |
pubs.organisational-group | University Institutes and Centers | |
pubs.publication-status | Published | |
pubs.volume | 54 |
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