IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.

Vidal, Adriana C

Skaar, David

Maguire, Rachel

Dodor, Seyram

Musselwhite, Laura W

Bartlett, John A

Oneko, Olola

Obure, Joseph

Mlay, Pendo

Murphy, Susan K

Hoyo, Cathrine

England

2016-08-19T13:34:39Z

2015

BACKGROUND: Despite comparable screening rates for precancerous lesions, higher incidence and mortality related to cervical cancer in minority women persists. Recent evidence suggests that minority women with precancerous cervical lesions harbor a wider range of human papillomavirus (HPV) genotypes, many of these distinct from HPV16/18, those most commonly found in Caucasian women. The goal of the analysis was to determine if inflammatory cytokines and chemokines varied by HPV 16/18 versus other genotypes in cervical cancer tissues from Tanzanian women. METHODS: HPV genotypes and concentrations of chemokines and cytokines were measured from homogenized fresh tumor tissue of thirty-one women with invasive cervical cancer (ICC). Risk factors for cervical cancer including age, parity, hormonal contraceptive use and cigarette smoking were obtained by questionnaire. Generalized linear models were used to evaluate differences between chemokines/cytokine levels in women infected with HPV16/18 and those infected with other HPV genotypes. RESULTS: After adjusting for age, parity and hormonal contraceptives, IL-17 was found significantly more frequently in invasive cervical cancer samples of women infected with HPV16/18 compared to women infected with other HPV genotypes (p = 0.033). In contrast, higher levels for granular macrophage colony-stimulating factor (p = 0.004), IL-10 (p = 0.037), and IL-15 (p = 0.041) were found in ICC tissues of women infected with genotypes other than HPV16/18 when compared to those of women infected with HPV16/18. CONCLUSIONS: While the small sample size limits inference, our data suggest that infection with different HPV genotypes is associated with distinct pro-inflammatory cytokine expression profiles; whether this explains some of the racial differences observed in cervical cancer is still unclear. Future studies are needed to confirm these findings.

http://www.ncbi.nlm.nih.gov/pubmed/25810759

5

https://hdl.handle.net/10161/12657

eng

Springer Science and Business Media LLC

Infect Agent Cancer

10.1186/s13027-015-0005-1

Case-only

Cytokines

Disparities

HPV infection

Invasive cervical cancer

Race

IL-10, IL-15, IL-17, and GMCSF levels in cervical cancer tissue of Tanzanian women infected with HPV16/18 vs. non-HPV16/18 genotypes.

Journal article

Murphy, Susan K|0000-0001-8298-7272

http://www.ncbi.nlm.nih.gov/pubmed/25810759

10

Clinical Science Departments

Duke

Duke Cancer Institute

Duke Science & Society

Global Health Institute

Initiatives

Institutes and Centers

Institutes and Provost's Academic Units

Medicine

Medicine, Infectious Diseases

Obstetrics and Gynecology

Obstetrics and Gynecology, Gynecologic Oncology

Pathology

School of Medicine

School of Nursing

School of Nursing - Secondary Group

Staff

University Institutes and Centers

Published online

10