Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study).
| dc.contributor.author | O'Neal, Wesley T | |
| dc.contributor.author | Wang, Yi Grace | |
| dc.contributor.author | Wu, Hau-Tieng | |
| dc.contributor.author | Zhang, Zhu-Ming | |
| dc.contributor.author | Li, Yabing | |
| dc.contributor.author | Tereshchenko, Larisa G | |
| dc.contributor.author | Estes, E Harvey | |
| dc.contributor.author | Daubechies, Ingrid | |
| dc.contributor.author | Soliman, Elsayed Z | |
| dc.coverage.spatial | United States | |
| dc.date.accessioned | 2017-09-01T13:32:22Z | |
| dc.date.available | 2017-09-01T13:32:22Z | |
| dc.date.issued | 2016-09-15 | |
| dc.description.abstract | The association between the J wave, a key component of the early repolarization pattern, and adverse cardiovascular outcomes remains unclear. Inconsistencies have stemmed from the different methods used to measure the J wave. We examined the association between the J wave, detected by an automated method, and adverse cardiovascular outcomes in 14,592 (mean age = 54 ± 5.8 years; 56% women; 26% black) participants from the Atherosclerosis Risk In Communities (ARIC) study. The J wave was detected at baseline (1987 to 1989) and during follow-up study visits (1990 to 1992, 1993 to 1995, and 1996 to 1998) using a fully automated method. Sudden cardiac death, coronary heart disease death, and cardiovascular mortality were ascertained from hospital discharge records, death certificates, and autopsy data through December 31, 2010. A total of 278 participants (1.9%) had evidence of a J wave. Over a median follow-up of 22 years, 4,376 of the participants (30%) died. In a multivariable Cox regression analysis adjusted for demographics, cardiovascular risk factors, and potential confounders, the J wave was not associated with an increased risk of sudden cardiac death (hazard ratio [HR] 0.74, 95% CI 0.36 to 1.50), coronary heart disease death (HR 0.72, 95% CI 0.40 to 1.32), or cardiovascular mortality (HR 1.16, 95% CI 0.87 to 1.56). An interaction was detected for cardiovascular mortality by gender with men (HR 1.54, 95% CI 1.09 to 2.19) having a stronger association than women (HR 0.74, 95% CI 0.43 to 1.25; P-interaction = 0.030). In conclusion, our findings suggest that the J wave is a benign entity that is not associated with an increased risk for sudden cardiac arrest in middle-aged adults in the United States. | |
| dc.identifier | ||
| dc.identifier | S0002-9149(16)31118-3 | |
| dc.identifier.eissn | 1879-1913 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Elsevier BV | |
| dc.relation.ispartof | Am J Cardiol | |
| dc.relation.isversionof | 10.1016/j.amjcard.2016.06.047 | |
| dc.subject | African Americans | |
| dc.subject | Brugada Syndrome | |
| dc.subject | Cardiovascular Diseases | |
| dc.subject | Cohort Studies | |
| dc.subject | Coronary Disease | |
| dc.subject | Death, Sudden, Cardiac | |
| dc.subject | Electrocardiography | |
| dc.subject | European Continental Ancestry Group | |
| dc.subject | Female | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Humans | |
| dc.subject | Male | |
| dc.subject | Middle Aged | |
| dc.subject | Multivariate Analysis | |
| dc.subject | Proportional Hazards Models | |
| dc.subject | Prospective Studies | |
| dc.subject | Risk Factors | |
| dc.subject | Sex Factors | |
| dc.subject | United States | |
| dc.title | Electrocardiographic J Wave and Cardiovascular Outcomes in the General Population (from the Atherosclerosis Risk In Communities Study). | |
| dc.type | Journal article | |
| duke.contributor.orcid | Wu, Hau-Tieng|0000-0002-0253-3156 | |
| pubs.author-url | ||
| pubs.begin-page | 811 | |
| pubs.end-page | 815 | |
| pubs.issue | 6 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | Electrical and Computer Engineering | |
| pubs.organisational-group | Mathematics | |
| pubs.organisational-group | Pratt School of Engineering | |
| pubs.organisational-group | Statistical Science | |
| pubs.organisational-group | Trinity College of Arts & Sciences | |
| pubs.publication-status | Published | |
| pubs.volume | 118 |