Incidence and Survival Among Young Women With Stage I-III Breast Cancer: SEER 2000-2015.
| dc.contributor.author | Thomas, Alexandra | |
| dc.contributor.author | Rhoads, Anthony | |
| dc.contributor.author | Pinkerton, Elizabeth | |
| dc.contributor.author | Schroeder, Mary C | |
| dc.contributor.author | Conway, Kristin M | |
| dc.contributor.author | Hundley, William G | |
| dc.contributor.author | McNally, Lacey R | |
| dc.contributor.author | Oleson, Jacob | |
| dc.contributor.author | Lynch, Charles F | |
| dc.contributor.author | Romitti, Paul A | |
| dc.date.accessioned | 2024-02-01T14:27:44Z | |
| dc.date.available | 2024-02-01T14:27:44Z | |
| dc.date.issued | 2019-09 | |
| dc.description.abstract | BackgroundAlthough recent findings suggest that de novo stage IV breast cancer is increasing in premenopausal women in the United States, contemporary incidence and survival data are lacking for stage I-III cancer.MethodsWomen aged 20-29 (n = 3826), 30-39 (n = 34 585), and 40-49 (n = 126 552) years who were diagnosed with stage I-III breast cancer from 2000 to 2015 were identified from the Surveillance, Epidemiology, and End Results 18 registries database. Age-adjusted, average annual percentage changes in incidence and 5- and 10-year Kaplan-Meier survival curves were estimated by race and ethnicity, stage, and hormone receptor (HR) status and grade (low to well and moderately differentiated; high to poorly and undifferentiated) for each age decade.ResultsThe average annual percentage change in incidence was positive for each age decade and was highest among women aged 20-29 years. Increased incidence was driven largely by HR+ cancer, particularly HR+ low-grade cancer in women aged 20-29 and 40-49 years. By 2015, incidence of HR+ low- and high-grade cancer each independently exceeded incidence of HR- cancer in each age decade. Survival for HR+ low- and high-grade cancer decreased with decreasing age; survival for HR- cancer was similar across age decades. Among all women aged 20-29 years, 10-year survival for HR+ high-grade cancer was lower than that for HR+ low-grade or HR- cancer. Among women aged 20-29 years with stage I cancer, 10-year survival was lowest for HR+ high-grade cancer.ConclusionsHR+ breast cancer is increasing in incidence among premenopausal women, and HR+ high-grade cancer was associated with reduced survival among women aged 20-29 years. Our findings can help guide further evaluation of preventive, diagnostic, and therapeutic strategies for breast cancer among premenopausal women. | |
| dc.identifier | pkz040 | |
| dc.identifier.issn | 2515-5091 | |
| dc.identifier.issn | 2515-5091 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Oxford University Press (OUP) | |
| dc.relation.ispartof | JNCI cancer spectrum | |
| dc.relation.isversionof | 10.1093/jncics/pkz040 | |
| dc.rights.uri | ||
| dc.title | Incidence and Survival Among Young Women With Stage I-III Breast Cancer: SEER 2000-2015. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Thomas, Alexandra|0000-0001-9022-2229 | |
| pubs.begin-page | pkz040 | |
| pubs.issue | 3 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Medical Oncology | |
| pubs.publication-status | Published | |
| pubs.volume | 3 |
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