The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway.

Loading...
Thumbnail Image

Date

2007-04

Authors

Turner, Elena A
Jarvis, Erich David

Journal Title

Journal ISSN

Volume Title

Repository Usage Stats

184
views
201
downloads

Citation Stats

Abstract

The discrete neural network for songbird vocal communication provides an effective system to study neural mechanisms of learned motor behaviors in vertebrates. This system consists of two pathways--a vocal motor pathway used to produce learned vocalizations and a vocal pallial basal ganglia loop used to learn and modify the vocalizations. However, it is not clear how the loop exerts control over the motor pathway. To study the mechanism, we used expression of the neural activity-induced gene ZENK (or egr-1), which shows singing-regulated expression in a social context-dependent manner: high levels in both pathways when singing undirected and low levels in the lateral part of the loop and in the robust nucleus of the arcopallium (RA) of the motor pathway when singing directed to another animal. Here, we show that there are two parallel interactive parts within the pallial basal ganglia loop, lateral and medial, which modulate singing-driven ZENK expression of the motor pathway nuclei RA and HVC, respectively. Within the loop, the striatal and pallial nuclei appear to have opposing roles; the striatal vocal nucleus lateral AreaX is required for high ZENK expression in its downstream nuclei, particularly during undirected singing, while the pallial vocal lateral magnocellular nucleus of the anterior nidopallium is required for lower expression, particularly during directed singing. These results suggest a dynamic molecular interaction between the basal ganglia pathway and the motor pathway during production of a learned motor behavior.

Department

Description

Provenance

Citation

Published Version (Please cite this version)

10.1111/j.1460-9568.2007.05368.x

Publication Info

Kubikova, L, Elena A Turner and Erich David Jarvis (2007). The pallial basal ganglia pathway modulates the behaviorally driven gene expression of the motor pathway. Eur J Neurosci, 25(7). pp. 2145–2160. 10.1111/j.1460-9568.2007.05368.x Retrieved from https://hdl.handle.net/10161/11265.

This is constructed from limited available data and may be imprecise. To cite this article, please review & use the official citation provided by the journal.


Unless otherwise indicated, scholarly articles published by Duke faculty members are made available here with a CC-BY-NC (Creative Commons Attribution Non-Commercial) license, as enabled by the Duke Open Access Policy. If you wish to use the materials in ways not already permitted under CC-BY-NC, please consult the copyright owner. Other materials are made available here through the author’s grant of a non-exclusive license to make their work openly accessible.