Effects of FOXO genotypes on longevity: a biodemographic analysis.

Zeng, Y; Cheng, L; Chen, H; Cao, H; Hauser, ER; Liu, Y; Xiao, Z; Tan, Q; Tian, XL; Vaupel, JW

Effects of FOXO genotypes on longevity: a biodemographic analysis.

dc.contributor.author	Zeng, Y
dc.contributor.author	Cheng, L
dc.contributor.author	Chen, H
dc.contributor.author	Cao, H
dc.contributor.author	Hauser, ER
dc.contributor.author	Liu, Y
dc.contributor.author	Xiao, Z
dc.contributor.author	Tan, Q
dc.contributor.author	Tian, XL
dc.contributor.author	Vaupel, JW
dc.coverage.spatial	United States
dc.date.accessioned	2017-06-02T19:34:08Z
dc.date.available	2017-06-02T19:34:08Z
dc.date.issued	2010-12
dc.description.abstract	Based on data from 760 centenarians and 1060 middle-age controls (all Han Chinese), this article contributes biodemographic insights and syntheses concerning the magnitude of effects of the FOXO genotypes on longevity. We also estimate independent and joint effects of the genotypes of FOXO1A and FOXO3A genes on long-term survival, considering carrying or not-carrying the minor allele of the single-nucleotide polymorphism of another relevant gene. We found substantial gender differences in the independent effects; positive effects of FOXO3A and negative effects of FOXO1A largely compensate each other if one carries both, although FOXO3A has a stronger impact. Ten-year follow-up cohort analysis shows that at very advanced ages 92-110, adjusted for various confounders, positive effects of FOXO3A on survival remain statistically significant, but no significant effects of FOXO1A alone; G × G interactions between FOXO1A-209 and FOXO3A-310 or FOXO3A-292 decrease survival likelihood by 32%-36% (p < .05); G × E interactions between FOXO1A-209 and regular exercise increase survival likelihood by 31%-32% (p < .05).
dc.identifier	https://www.ncbi.nlm.nih.gov/pubmed/20884733
dc.identifier	glq156
dc.identifier.eissn	1758-535X
dc.identifier.uri	https://hdl.handle.net/10161/14784
dc.language	eng
dc.publisher	Oxford University Press (OUP)
dc.relation.ispartof	J Gerontol A Biol Sci Med Sci
dc.relation.isversionof	10.1093/gerona/glq156
dc.subject	Aged, 80 and over
dc.subject	Asian Continental Ancestry Group
dc.subject	Cohort Studies
dc.subject	Female
dc.subject	Forkhead Box Protein O1
dc.subject	Forkhead Box Protein O3
dc.subject	Forkhead Transcription Factors
dc.subject	Genotype
dc.subject	Heterozygote
dc.subject	Humans
dc.subject	Likelihood Functions
dc.subject	Longevity
dc.subject	Longitudinal Studies
dc.subject	Male
dc.subject	Middle Aged
dc.subject	Probability
dc.subject	Proportional Hazards Models
dc.subject	Sex Factors
dc.subject	Survival Analysis
dc.title	Effects of FOXO genotypes on longevity: a biodemographic analysis.
dc.type	Journal article
duke.contributor.orcid	Hauser, ER\|0000-0003-0367-9189
pubs.author-url	https://www.ncbi.nlm.nih.gov/pubmed/20884733
pubs.begin-page	1285
pubs.end-page	1299
pubs.issue	12
pubs.organisational-group	Basic Science Departments
pubs.organisational-group	Biostatistics & Bioinformatics
pubs.organisational-group	Center for Population Health & Aging
pubs.organisational-group	Center for the Study of Aging and Human Development
pubs.organisational-group	Clinical Science Departments
pubs.organisational-group	Duke
pubs.organisational-group	Duke Molecular Physiology Institute
pubs.organisational-group	Duke Population Research Center
pubs.organisational-group	Duke Population Research Institute
pubs.organisational-group	Institutes and Centers
pubs.organisational-group	Medicine
pubs.organisational-group	Medicine, Geriatrics
pubs.organisational-group	Sanford School of Public Policy
pubs.organisational-group	School of Medicine
pubs.publication-status	Published
pubs.volume	65

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