Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Skytthe, A

Valensin, S

Jeune, B

Cevenini, E

Balard, F

Beekman, M

Bezrukov, V

Blanche, H

Bolund, L

Broczek, K

Carru, C

Christensen, K

Christiansen, L

Collerton, JC

Cotichini, R

de Craen, AJM

Dato, S

Davies, K

De Benedictis, G

Deiana, L

Flachsbart, F

Gampe, J

Gilbault, C

Gonos, ES

Haimes, E

Hervonen, A

Hurme, MA

Janiszewska, D

Jylhä, M

Kirkwood, TBL

Kristensen, P

Laiho, P

Leon, A

Marchisio, A

Masciulli, R

Nebel, A

Passarino, G

Pelicci, G

Peltonen, L

Perola, M

Poulain, M

Rea, IM

Remacle, J

Robine, JM

Schreiber, S

Scurti, M

Sevini, F

Sikora, E

Skouteri, A

Slagboom, PE

Spazzafumo, L

Stazi, MA

Toccaceli, V

Toussaint, O

Törnwall, O

Vaupel, JW

Voutetakis, K

Franceschi, C

GEHA consortium

England

2017-06-02T19:31:54Z

2017-06-02T19:31:54Z

2011-11

In 2004, the integrated European project GEHA (Genetics of Healthy Ageing) was initiated with the aim of identifying genes involved in healthy ageing and longevity. The first step in the project was the recruitment of more than 2500 pairs of siblings aged 90 years or more together with one younger control person from 15 areas in 11 European countries through a coordinated and standardised effort. A biological sample, preferably a blood sample, was collected from each participant, and basic physical and cognitive measures were obtained together with information about health, life style, and family composition. From 2004 to 2008 a total of 2535 families comprising 5319 nonagenarian siblings were identified and included in the project. In addition, 2548 younger control persons aged 50-75 years were recruited. A total of 2249 complete trios with blood samples from at least two old siblings and the younger control were formed and are available for genetic analyses (e.g. linkage studies and genome-wide association studies). Mortality follow-up improves the possibility of identifying families with the most extreme longevity phenotypes. With a mean follow-up time of 3.7 years the number of families with all participating siblings aged 95 years or more has increased by a factor of 5 to 750 families compared to when interviews were conducted. Thus, the GEHA project represents a unique source in the search for genes related to healthy ageing and longevity.

https://www.ncbi.nlm.nih.gov/pubmed/21871552

S0531-5565(11)00204-X

1873-6815

https://hdl.handle.net/10161/14783

eng

Elsevier BV

Exp Gerontol

10.1016/j.exger.2011.08.005

Aged

Aged, 80 and over

Aging

Cognition

Europe

Family

Female

Genetic Linkage

Genome-Wide Association Study

Humans

Life Style

Longevity

Male

Middle Aged

Patient Selection

Research Design

Surveys and Questionnaires

Design, recruitment, logistics, and data management of the GEHA (Genetics of Healthy Ageing) project.

Journal article

https://www.ncbi.nlm.nih.gov/pubmed/21871552

934

945

11

Center for Population Health & Aging

Duke

Duke Population Research Institute

Sanford School of Public Policy

Published

46