Type-2 diabetes, pancreatic amylin and neuronal metabolic remodeling in Alzheimer's Disease.
| dc.contributor.author | Leibold, Noah | |
| dc.contributor.author | Bain, James R | |
| dc.contributor.author | Despa, Florin | |
| dc.date.accessioned | 2023-02-01T19:01:38Z | |
| dc.date.available | 2023-02-01T19:01:38Z | |
| dc.date.issued | 2023-01-28 | |
| dc.date.updated | 2023-02-01T19:01:37Z | |
| dc.description.abstract | Type-2 diabetes raises the risk for Alzheimer's disease (AD)-type dementia and the conversion from mild cognitive impairment to dementia, yet mechanisms connecting type-2 diabetes to AD remain largely unknown. Amylin, a pancreatic β-cell hormone co-secreted with insulin, participates in the central regulation of satiation, but also forms pancreatic amyloid in persons with type-2 diabetes and synergistically interacts with brain amyloid β (Aβ) pathology, in both sporadic and familial Alzheimer's disease (AD). Growing evidence from studies of tumor growth, together with early observations in skeletal muscle, indicate amylin as a potential trigger of cellular metabolic reprogramming. Because the blood, cerebrospinal fluid, and brain parenchyma in humans with AD have increased concentrations of amylin, amylin-mediated pathological processes in the brain may involve neuronal metabolic remodeling. We summarize recent progress in understanding the link between prediabetic hypersecretion of amylin and risk of neuronal metabolic remodeling and AD and suggest nutritional and medical effects of food constituents that might prevent and/or ameliorate amylin-mediated neuronal metabolic remodeling. This article is protected by copyright. All rights reserved. | |
| dc.identifier.issn | 1613-4125 | |
| dc.identifier.issn | 1613-4133 | |
| dc.identifier.uri | ||
| dc.language | eng | |
| dc.publisher | Wiley | |
| dc.relation.ispartof | Mol Nutr Food Res | |
| dc.relation.isversionof | 10.1002/mnfr.202200405 | |
| dc.subject | Alzheimer's disease | |
| dc.subject | amylin | |
| dc.subject | diabetes | |
| dc.subject | metabolism | |
| dc.subject | vascular cognitive impairment and dementia (VCID) | |
| dc.title | Type-2 diabetes, pancreatic amylin and neuronal metabolic remodeling in Alzheimer's Disease. | |
| dc.type | Journal article | |
| duke.contributor.orcid | Bain, James R|0000-0002-8917-9187 | |
| pubs.begin-page | e2200405 | |
| pubs.organisational-group | Duke | |
| pubs.organisational-group | School of Medicine | |
| pubs.organisational-group | Clinical Science Departments | |
| pubs.organisational-group | Institutes and Centers | |
| pubs.organisational-group | Medicine | |
| pubs.organisational-group | Medicine, Endocrinology, Metabolism, and Nutrition | |
| pubs.organisational-group | Duke Molecular Physiology Institute | |
| pubs.organisational-group | Sarah Stedman Nutrition & Metabolism Center | |
| pubs.organisational-group | Center for the Study of Aging and Human Development | |
| pubs.publication-status | Published online |
Files
Original bundle
- Name:
- Leibold_Bain_and_Despa_Molecular Nutrition and Food Research 2023_Type‐2 diabetes-pancreatic amylin and neuronal metabolic remodeling in Alzheimer's Disease.pdf
- Size:
- 1.75 MB
- Format:
- Adobe Portable Document Format
- Description:
- Submitted version